PMID: 9548608Apr 21, 1998Paper

Intra-arterial infusion: overview and novel approaches

Seminars in Surgical Oncology
K R Aigner

Abstract

Intra-arterial infusion includes a variety of treatment modalities, adjusted selectively to chemosensitivity and vascularization. For most drugs, response behaviour of different tumors is concentration dependent and requires improved modes of application of cytotoxics. In the treatment of liver metastases from colorectal cancer and hepatocellular carcinoma, blood flow reduction by micro-embolization with starch microspheres has brought significant advantage in response. Balloon stopflow infusion combined with micro-embolization induced 83% complete remissions in a study including 100 patients with locally recurrent breast cancer. Stepwise increased local exposure demonstrated concentration-dependent response. Stopflow infusion of the celiac axis combined with microspheres for advanced Stage III and IV pancreatic cancer induced a 96% remission rate (n = 24 patients) at a median survival of 10 months. This was confirmed in a series of consecutive studies including 242 patients. Quality of life was significantly improved in all responding patients. Overall pain response was 80%. A prospective randomized trial in this patient group, comparing systemic vs. regional chemotherapy in the form of intra-arterial infusion with tumor adjus...Continue Reading

References

Jul 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P RougierD Gallot
Jan 1, 1991·Cancer Treatment and Research·K R AignerH Müller
Jun 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A P VenookD C Hohn
Aug 15, 1986·International Journal of Cancer. Journal International Du Cancer·S Rockwell
Feb 1, 1987·Investigative Radiology·J R DanielsE J Ring
Sep 1, 1995·The Journal of Surgical Research·A M AverbachP H Sugarbaker

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Citations

Dec 6, 2014·Journal of Neuroanaesthesiology and Critical Care·Shailendra JoshiCharles W Emala
Mar 26, 2014·Journal of Neuro-oncology·Shailendra JoshiRobert M Straubinger
Jun 1, 2005·Seminars in Interventional Radiology·Aalpen A PatelMichael C Soulen
Sep 10, 2002·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P PilatiM Lise
Sep 13, 2001·British Journal of Haematology·L CambaM Giacomelli
Sep 1, 2016·Journal of Neuro-oncology·Jason A EllisShailendra Joshi

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