Abstract
The mechanism of adaptation to chronic cerebral hypotension in normal brain adjacent to cerebral arteriovenous malformations (AVMs) is unknown. To clarify these mechanisms, we performed cerebral blood flow (CBF) studies in structurally and functionally normal vascular territories during 53 distal cerebral angiographic procedures in 37 patients with AVMs. CBF was measured using the superselective intra-arterial 133Xe method before and after a 3-minute infusion of either verapamil (1 mg.min-1, n = 23), acetylcholine (1.33 micrograms.kg-1.min-1, n = 7), nitroprusside (0.5 microgram.kg-1.min-1, n = 16) or nitroglycerin (0.5 microgram.kg-1.min-1, n = 7). Mean +/- SD systemic (76 +/- 13 mm Hg) and distal cerebral arterial (55 +/- 16 mm Hg; range, 20 to 97 mm Hg) pressures were not different among groups. Verapamil increased CBF (45 +/- 12 to 65 +/- 21 mL.100 g-1.min-1, P < .001). There was no effect of acetylcholine (no change [46 +/- 9 to 46 +/- 9 mL.100 g-1.min-1], NS) or nitroglycerin (36 +/- 14 to 36 +/- 13 mL.100 g-1.min-1, NS). Nitroprusside decreased CBF (40 +/- 12 to 31 +/- 11 mL.100 g-1.min-1, P < .001). The percent change in CBF after drug administration was proportional to cerebral arterial pressure for verapamil only (r =...Continue Reading
References
Jan 1, 1978·Acta neurochirurgica·L Auer
Oct 1, 1976·Journal of Neurosurgery·M MatsudaY Tagashira
Jan 1, 1976·Anesthesiology·A D IvankovichB Zahed
Oct 1, 1992·Hypertension·T ImaizumiA Takeshita
Nov 15, 1992·The American Journal of Cardiology·J L Dubois-RandéS Adnot
Jul 1, 1992·British Journal of Pharmacology·J L GarcíaG Diéguez
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S MoncadaR M Palmer
Jul 1, 1991·British Journal of Pharmacology·S M GardinerT Bennett
Aug 1, 1990·Neurosurgery·W L YoungB M Stein
Oct 1, 1990·Anesthesiology·W L YoungN Ostapkovich
Jan 1, 1986·Clinical Neuropharmacology·R A DierckxL Corne
Aug 7, 1985·European Journal of Pharmacology·Y Shirasaki, C Su
Aug 1, 1971·Journal of Neurosurgery·W FeindelC P Hodge
Feb 1, 1983·Acta Anaesthesiologica Scandinavica·L HenriksenO B Paulson
Dec 1, 1993·Journal of Cardiovascular Pharmacology·G A RongenT Thien
May 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P Hylland, G E Nilsson
Jul 1, 1993·Journal of Cardiovascular Pharmacology·T A BruningP A van Zwieten
Apr 1, 1995·The Journal of Clinical Investigation·A A QuyyumiR O Cannon
Apr 1, 1995·The American Journal of Physiology·W M Armstead
Jul 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F Zhang, C Iadecola
Jul 1, 1994·The American Journal of Physiology·U DirnaglA Villringer
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F ZhangC Iadecola
Apr 1, 1994·Hypertension·S TaddeiA Salvetti
Sep 1, 1993·British Journal of Pharmacology·N FernándezG Diéguez
Feb 1, 1994·Anesthesiology·W L Young, J Pile-Spellman
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Q WangN A Lassen
Aug 1, 1993·The American Journal of Physiology·T KitazonoF M Faraci
Apr 1, 1993·Neurosurgery·W L YoungB M Stein
May 1, 1993·Neuroreport·F Zhang, C Iadecola
Jan 1, 1996·Journal of Neurosurgery·B G ThompsonE H Oldfield
Sep 1, 1996·Journal of Neurosurgery·P Fogarty-MackW L Young
Citations
Jan 15, 2013·European Journal of Applied Physiology·Christopher K WillieYu-Chieh Tzeng
Feb 13, 2001·European Journal of Pharmacology·K CseteJ G Papp
Oct 6, 2000·Journal of the Neurological Sciences·R P WhiteH S Markus
Dec 8, 1998·Anesthesia and Analgesia·S JoshiN Ostapkovich
Jan 29, 2002·Anesthesia and Analgesia·Shailendra JoshiJohn Pile-Spellman
Mar 23, 2005·Anesthesia and Analgesia·Roger HartlRobert R Sciacca
Apr 13, 2002·Neurosurgery·Ketan R BulsaraCarmelo Graffagnino
Sep 1, 2004·Neurosurgery·John L UlmerKathleen M Schmainda
Apr 7, 2007·Neurosurgery·Sean D LavineShailendra Joshi
Jul 26, 2005·Neurologia Medico-chirurgica·Ichiro NakagawaToshisuke Sakaki
Nov 3, 2009·Journal of Neurosurgery·Erminia AlbaneseArthur J Ulm
Feb 10, 2006·Neurosurgical Focus·C StapfE S Connolly
Jul 6, 2014·Neurosurgery Clinics of North America·Christopher D Baggott, Beverley Aagaard-Kienitz
Apr 11, 2001·Journal of Neurosurgical Anesthesiology·S JoshiW L Young
Oct 4, 2006·Current Opinion in Anaesthesiology·S Krayer
Sep 2, 2000·Anesthesiology·S JoshiJ Pile-Spellman
Dec 26, 2001·Anesthesiology·Shailendra JoshiJohn Pile-Spellman
Jan 29, 2003·Anesthesiology·Shailendra JoshiCarol A Hirshman
Apr 17, 2004·Anesthesiology·Shailendra JoshiDaniel H Sahlein
Mar 17, 2000·Current Opinion in Neurology·C Stapf, J P Mohr
Jan 29, 2016·Journal of Drug Delivery·Jason A EllisShailendra Joshi
Feb 22, 2008·Best Practice & Research. Clinical Anaesthesiology·Armin Schubert
Oct 1, 2008·Neurosurgery·Carsten StüerBernhard Meyer
Feb 5, 2011·Journal of Applied Physiology·Gregory S H ChanYu-Chieh Tzeng