PMID: 9631632Jun 19, 1998Paper

Intra-arterial papaverine treatment for cerebral vasospasm: our experience and review of the literature

Neurologia Medico-chirurgica
Y Numaguchi, G H Zoarski

Abstract

We described the techniques and efficacy of intra-arterial papaverine hydrochloride infusion (IA-PAP) for symptomatic vasospasm due to aneurysmal subarachnoid hemorrhage based on our experience and review of the literature. Angiographic improvement occurred almost always, but only 50% of patients who presented with acute symptoms showed remarkable clinical improvement after the first, second, or third IA-PAP. Recurrent vasospasm after IA-PAP frequently occurred and this seems to be an apparent source of controversy regarding its efficacy. Review of the literature indicates that IA-PAP may be most effective in combination with percutaneous transluminal angioplasty. Further controlled studies should be conducted regarding papaverine's true efficacy including most effective papaverine concentration and rate of infusion, maximum total dose, site of infusion, timing of treatment, and selection of patients.

Citations

Nov 30, 2000·Current Treatment Options in Neurology·K D FlemmingD O Wiebers
Jul 16, 2011·Neurocritical Care·Matthew M KimballUNKNOWN Participants in the International Multi-Disciplinary Consensus Conference on the Critical Care Management of Subarachnoid He
May 12, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·J BerréL Puybasset
Oct 13, 2001·Surgical Neurology·J R CarhuapomaD F Hanley
Mar 15, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·S NagaoY Matsumoto
Apr 23, 2004·Journal of Vascular and Interventional Radiology : JVIR·J J Connors
Sep 10, 2008·Neuroscience Letters·Ayse KaratasSeyit Ankarali
Jun 16, 2007·Journal of the Neurological Sciences·Ricardo J KomotarE Sander Connolly

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