PMID: 3747029Sep 1, 1986Paper

Intra-arterial streptokinase therapy to relieve acute limb ischemia

Journal of Vascular Surgery
L J FergusonJ H Miller

Abstract

One hundred two patients with acute lower limb ischemia were treated with intra-arterial streptokinase. Thirty-seven patients had occluded vascular grafts and sixty-five had had no previous vascular surgery. Eighty-six limbs were acutely threatened. Intra-arterial streptokinase was given as an initial loading dose with a lower maintenance dose given afterward. The mean duration of therapy was 59 hours and hematologic monitoring was meticulous. Indications for intra-arterial streptokinase therapy were contraindication to surgery, anticipation of technically difficult surgery, and multiple occlusions that required separate surgical approaches. Seventy-two legs were saved (71%) and 30 amputated. Morbidity was low and only 1 of the 11 deaths was attributable to streptokinase. No leg was lost that would otherwise have been saved by straightforward surgery and no leg was lost that had not been previously threatened. In 46 patients for whom emergency femorotibial bypass would have been necessary, 35 legs (76%) were saved. Forty-three patients had vascular reconstruction immediately after streptokinase therapy was stopped, to bypass occlusive lesions that had been demonstrated by the thrombolytic therapy in 28 patients, and because str...Continue Reading

References

Apr 1, 1974·Radiology·C T DotterA J Seaman
Nov 1, 1983·Radiology·J M EskridgeE C Klatte
Jun 1, 1981·AJR. American Journal of Roentgenology·B T Katzen, A van Breda
Aug 1, 1983·Annals of Surgery·G A BerniD E Strandness

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Citations

Mar 21, 2009·Seminars in Vascular Surgery·William P Robinson, Michael Belkin
May 1, 1990·Clinical Radiology·W J Walker, A E Giddings
Mar 6, 2002·Journal of Vascular Surgery·Bettina MartyLudwig Karl von Segesser
Nov 1, 1987·American Journal of Surgery·J B Towne, D F Bandyk
Aug 1, 1990·European Journal of Vascular Surgery·J J EarnshawG S Makin
May 1, 1993·Annals of Vascular Surgery·G L Faggioli, J J Ricotta
Oct 1, 1991·Circulation·M ArianiR J Siegel
Mar 1, 1997·The British Journal of Surgery·I DawsonJ H van Bockel
Feb 1, 1990·The British Journal of Surgery·D C BerridgeB R Hopkinson
Jan 1, 1992·The British Journal of Surgery·D J BrowseR B Galland
Mar 1, 1991·The British Journal of Surgery·J J Earnshaw
Oct 1, 1990·The British Journal of Surgery·R C BowyerA E Giddings
Sep 1, 1993·The British Journal of Surgery·R B GallandG Hamilton
Jun 1, 1996·The British Journal of Surgery·K IhnkenU Unkelbach
Mar 1, 1989·The British Journal of Surgery·K T MoranA V Persson
Mar 1, 1995·Postgraduate Medical Journal·J Golledge, R B Galland
Jan 1, 1994·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·F BeyersdorfP Satter

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