Intra-Arterial Therapy and Post-Treatment Infarct Volumes: Insights From the ESCAPE Randomized Controlled Trial

Stroke; a Journal of Cerebral Circulation
Fahad S Al-AjlanESCAPE Trial Investigators

Abstract

The goal of reperfusion therapy in acute ischemic stroke is to limit brain infarction. The objective of this study was to investigate whether the beneficial effect of endovascular treatment on functional outcome could be explained by a reduction in post-treatment infarct volume. The Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times (ESCAPE) trial was a multicenter randomized open-label trial with blinded outcome evaluation. Among 315 enrolled subjects (endovascular treatment n=165; control n=150), 314 subject's infarct volumes at 24 to 48 hours on magnetic resonance imaging (n=254) or computed tomography (n=60) were measured. Post-treatment infarct volumes were compared by treatment assignment and recanalization/reperfusion status. Appropriate statistical models were used to assess relationship between baseline clinical and imaging variables, post-treatment infarct volume, and functional status at 90 days (modified Rankin Scale). Median post-treatment infarct volume in all subjects was 21 mL (interquartile range =65 mL), in the intervention arm, 15.5 mL (interquartile range =41.5 mL), and in the control arm, 33.5 mL (interquartile range =84 m...Continue Reading

Associated Clinical Trials

References

Jul 19, 2003·Stroke; a Journal of Cerebral Circulation·Randall T HigashidaUNKNOWN Technology Assessment Committee of the Society of Interventional Radiology
Aug 8, 2009·International Journal of Stroke : Official Journal of the International Stroke Society·T J QuinnK R Lees
May 26, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Jayme C KosiorUNKNOWN PREDICT/Sunnybrook CTA ICH study investigators
Jul 21, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bruce C V CampbellUNKNOWN EPITHET–DEFUSE Investigators
Mar 20, 2012·Stroke; a Journal of Cerebral Circulation·Albert J YooR Gilberto González
Dec 30, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Andrew M DemchukMichael D Hill
Feb 12, 2015·The New England Journal of Medicine·Mayank GoyalUNKNOWN ESCAPE Trial Investigators

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Citations

Nov 25, 2017·AJNR. American Journal of Neuroradiology·F S Al-AjlanUNKNOWN REVASCAT Investigators
Mar 30, 2017·Stroke; a Journal of Cerebral Circulation·Amber BuckerUNKNOWN MR CLEAN Trial Investigators (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in t
Jan 8, 2017·Stroke; a Journal of Cerebral Circulation·Sònia AbilleiraUNKNOWN Catalan Stroke Code and Reperfusion Consortium
Nov 30, 2019·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Adam A DmytriwVictor Xd Yang
Feb 28, 2020·Stroke; a Journal of Cerebral Circulation·Shashank AgarwalShadi Yaghi
Jun 10, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Aravind GaneshMayank Goyal
Nov 23, 2017·Frontiers in Neurology·Claus Z SimonsenGrethe Andersen
May 10, 2018·Stroke; a Journal of Cerebral Circulation·Robert WannamakerKenneth Butcher
Feb 8, 2019·Stroke; a Journal of Cerebral Circulation·Thabele M Leslie-MazwiGregory W Albers
Jan 10, 2018·Annals of Neurology·Yu XieUNKNOWN THRACE investigators
Jan 28, 2017·Frontiers in Neurology·Julian Schröder, Götz Thomalla
Jul 11, 2018·European Radiology·K C J CompagneUNKNOWN MR CLEAN Investigators
Mar 21, 2019·Current Pharmaceutical Design·Keita ShibataKoji Nobe
Oct 8, 2020·Neuroradiology·Ronen R LekerJose E Cohen
Nov 27, 2020·Journal of Neurointerventional Surgery·Bijoy K MenonUNKNOWN ESCAPE-NA1 investigators
Jun 26, 2021·AJNR. American Journal of Neuroradiology·J M OspelUNKNOWN ESCAPE-NA1 investigators
Sep 4, 2021·International Journal of Clinical Practice·Xianbing Meng, Jianwen Ji
May 8, 2018·World Neurosurgery·Yun-Cai RanJing-Liang Cheng

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