Intra-articular calcium phosphate cement: Its fate and impact on joint tissues in a rabbit model

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
C BraunA Gisep

Abstract

Clinical application of injectable ceramic cement in comminuted fractures revealed penetration of the viscous paste into the joint space. Not much is known on the fate of this cement and its influence on articular tissues. The purpose of this experimental study was to assess these unknown alterations of joint tissues after intra-articular injection of cement in a rabbit knee. Observation periods were from 1 week up to 24 months, with three rabbits per group. Norian SRS cement was injected into one knee joint, the contralateral side receiving the same volume of Ringers' solution. Light microscopic evaluation of histologic sections was performed, investigating the appearance of the cement, inflammatory reactions, and degenerative changes of the articular surface. No signs of pronounced acute or chronic inflammation were visible. The injected cement was mainly found as a single particle, anterior to the cruciate ligaments. It became surrounded by synovial tissues within 4 weeks and showed signs of superficial resorption. In some specimens, bone formation was seen around the cement. Degeneration of the articular surface showed no differences between experimental and control side, and no changes over time became apparent. No major d...Continue Reading

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Citations

Dec 22, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gerjon HanninkPieter Buma
Jan 1, 2013·Journal of Functional Biomaterials·Sergey V Dorozhkin
Sep 9, 2008·Journal of Orthopaedic Trauma·Norbert Suhm, Armando Gisep

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