Intra-articular clearance of labeled dextrans from naive and arthritic rat knee joints

Journal of Controlled Release : Official Journal of the Controlled Release Society
Timothy K MwangiLori A Setton

Abstract

Determine the effects of arthritis on the trans-synovial clearance of small and large model compounds following local delivery to the knee joint in a rat model. Intra-articular delivery was studied in rat knee joints in an osteoarthritis model of joint instability (medial collateral ligament and meniscus transection model or MMT). Fluorescently-labeled 10 kDa or 500 kDa dextran was injected in the arthritic or unoperated control (naive) joints 3 weeks after surgical destabilization, and the temporal clearance pattern was evaluated via in vivo regional fluorescence imaging, dextran concentrations in plasma and draining lymph nodes, and by quantification of fluorescence in histological synovium sections. Together these data were used to evaluate the effect of osteoarthritis and solute size on the rate of drug clearance from the joint. Clearance of 10 kDa dextran from the joint space quantified using in vivo fluorescence imaging of the knee joint region was not significantly different between naive and MMT joints. In contrast, clearance of 500 kDa dextran was significantly reduced for MMT joints when compared to naive joints by fluorescence in vivo imaging. Drug accumulation in lymph nodes and plasma were lower for the 500 kDa dex...Continue Reading

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Citations

Sep 12, 2018·Tissue Engineering. Part a·Robert M StefaniClark T Hung
Aug 14, 2019·Regenerative Biomaterials·Derek T HolyoakAnkur Singh
Jan 27, 2021·Annals of Biomedical Engineering·Young GuangLori A Setton
Mar 12, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tobias SiefenAlf Lamprecht

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