Intra-articular drug delivery systems: Overcoming the shortcomings of joint disease therapy

Expert Opinion on Drug Delivery
Helen M BurtLinda S Liang

Abstract

Intra-articular drug delivery is very useful for treating local disease flare-ups, synovitis and pain in joints. However, the effectiveness of drugs following intra-articular administration is limited by drug delivery issues. This review addresses critical drug delivery parameters that influence the biocompatibility, tolerability and efficacy of intra-articular administrations and offers an opinion on aspects of formulation design. The relevant literature was reviewed, focusing on factors influencing tissue targeting, safety and effectiveness of particulate formulations. Therapeutic applications of novel drug delivery systems for the localized treatment of joints have lagged significantly. Future innovations in the field will require the discovery of new therapeutic agents for regional delivery, combination regimens, novel biomaterials as drug carriers and targeting carriers to specific molecules.

References

Jan 1, 1992·European Journal of Clinical Pharmacology·G NeanderA Grahnen
May 1, 1990·Journal of Clinical Pharmacology·H DerendorfE van Vliet-Daskalopoulou
Dec 1, 1989·The Journal of Physiology·J R Levick, J N McDonald
Jan 1, 1988·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·P KnoxJ N McDonald
Apr 1, 1985·Arthritis and Rheumatism·W J WallisD M Foster
Mar 1, 1986·Clinical Pharmacology and Therapeutics·H DerendorfG Gyselby
Jan 1, 1981·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·F N GhadiallyR Ghadially
Jul 1, 1984·The Journal of Pharmacy and Pharmacology·J H RatcliffeS S Davis
Oct 1, 1983·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·A D Knight, J R Levick
Dec 1, 1994·Biomaterials·G PelusoG Balsamo
Jan 1, 1995·Journal of Biomaterials Science. Polymer Edition·E Pişkin
Mar 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P E GreisC H Evans
Sep 1, 1995·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·J R Levick
Jan 1, 1997·Annals of the Rheumatic Diseases·P KlempM C Robertson
Jul 1, 1997·Biological & Pharmaceutical Bulletin·N OhzawaJ Ishiguro
Feb 1, 2000·Baillière's Best Practice & Research. Clinical Rheumatology·W B van den Berg, B Bresnihan
Jun 6, 2000·Advanced Drug Delivery Reviews·M S Shive, J M Anderson
Jul 17, 2001·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·B BragdonS E Weisbrode
Dec 6, 2001·Advanced Drug Delivery Reviews·N KumarA J Domb
Jul 10, 2002·Clinical Pharmacokinetics·Ulla LindqvistHans Lundqvist
May 31, 2003·Nature Reviews. Drug Discovery·Josef S Smolen, Günter Steiner
Mar 5, 2004·Journal of Pharmaceutical Sciences·Linda S LiangHelen M Burt
Aug 19, 2004·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·R T LigginsH M Burt
Aug 25, 2004·The Journal of Pharmacy and Pharmacology·Hetal ThakkarR S R Murthy
May 12, 2005·International Journal of Pharmaceutics·Selcan TürkerSalih Deveci
Aug 9, 2005·Seminars in Arthritis and Rheumatism·Piercarlo Sarzi-PuttiniBianca Canesi
Apr 1, 2006·Advanced Drug Delivery Reviews·Nicole GerwinAndrea Lucke
Nov 21, 2007·Journal of Liposome Research·Scott H R EdwardsRichard A Read

❮ Previous
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Citations

Nov 6, 2013·Nature Reviews. Rheumatology·Christopher H EvansLori A Setton
Dec 1, 2009·Tissue Engineering. Part B, Reviews·Kyle D AllenLori A Setton
Feb 3, 2016·Advanced Healthcare Materials·Khosrow KhodabandehlouJoseph M DeSimone
Feb 9, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sinéad M RyanDavid J Brayden
Apr 23, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ambika G BajpayeeRyan M Porter
Sep 13, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhi-peng ChenJinhuo Pan
May 20, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anna MeroGianfranco Pasut
Jul 14, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Savas Guner, Orhan Buyukbebeci
Jan 30, 2018·Journal of Drug Targeting·Xun Feng, Yang Chen
Aug 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Adrian SulistioRussell J Tait
Jan 28, 2019·Acta Biomaterialia·Shichao ZhangBingyun Li
Apr 22, 2018·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Rea D SignorellJean-Christophe Leroux
Apr 7, 2021·Acta Biomaterialia·Molly KlimakFarshid Guilak
May 31, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Timothy K MwangiLori A Setton

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