Intra-articular injections in thumb osteoarthritis: A systematic review and meta-analysis of randomized controlled trials

Joint, Bone, Spine : Revue Du Rhumatisme
Sabine TrelluLaure Gossec

Abstract

The objective was to assess the efficacy of intra-articular injections of corticosteroids or hyaluronic acid in thumb osteoarthritis. A systematic review of the literature was performed until August 2014. All controlled trials reporting the efficacy on pain, functional capacity and pulp pinch force of hyaluronic acid or corticosteroids in thumb osteoarthritis were selected. Pooled standardized response means (SRMs) were assessed by meta-analysis. Six trials were included and contributed to 3 meta-analyses (hyaluronic acid versus placebo, corticosteroids vs. placebo and hyaluronic acid vs. corticosteroids). Among the 428 patients included, 169 were treated with hyaluronic acid, 147 with corticosteroids and 74 with placebo. Versus placebo at week 12, hyaluronic acid (2 trials, 148 patients) lead to better functional capacity (SRM -1.14 [-1.69; -0.60]) with no difference on pain; corticosteroids (2 trials, 164 patients) lead to no difference on pain or function. When comparing hyaluronic acid vs. corticosteroids (4 trials, 304 patients), no difference was evidenced until week 12. At week 24, pain was significantly lower in the corticosteroids group (SRM 1.44 [0.14; 2.74]) and pulp pinch force higher in the hyaluronic acid group (S...Continue Reading

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Citations

Dec 10, 2015·Drugs & Aging·Féline P B KroonMargreet Kloppenburg
Oct 11, 2015·Joint, Bone, Spine : Revue Du Rhumatisme·Christian Hubert Roux, Liana Euller-Ziegler
Aug 2, 2016·Expert Review of Clinical Immunology·Mohammed S Osman, Walter P Maksymowych
Oct 4, 2016·Der Unfallchirurg·T LögtersJ Windolf
Mar 10, 2018·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Ivan Medina-Porqueres, Raquel Cantero-Tellez
Nov 15, 2017·BMC Musculoskeletal Disorders·Sara TentiAntonella Fioravanti
Oct 12, 2018·Nature Reviews. Rheumatology·Michelle MarshallKrysia Dziedzic
Sep 25, 2017·AJR. American Journal of Roentgenology·Dermot J BowdenEoin C Kavanagh
Jul 2, 2020·Wiener klinische Wochenschrift·Nicola VeroneseLeonardo Punzi
May 1, 2021·Frontiers in Pharmacology·Sara TentiAntonella Fioravanti
Jan 15, 2021·American Journal of Physical Medicine & Rehabilitation·Kamal MezianLevent Özçakar
Jun 4, 2021·The Journal of Hand Surgery·Mia M QinDavid M Kalainov

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