Intra-Articular Synovial Sarcomas: Incidence and Differentiating Features from Localized Pigmented Villonodular Synovitis

Sarcoma
D NordemarM Skorpil

Abstract

Purpose. To determine the incidence of intra-articular synovial sarcomas and investigate if any radiological variables can differentiate them from localized (unifocal) pigmented villonodular synovitis (PVNS) and if multivariate data analysis could be used as a complementary clinical tool. Methods. Magnetic resonance images and radiographs of 7 cases of intra-articular synovial sarcomas and 14 cases of localized PVNS were blindedly reviewed. Variables analyzed were size, extra-articular growth, tumor border, blooming, calcification, contrast media enhancement, effusion, bowl of grapes sign, triple signal intensity sign, synovial low signal intensity, synovitis, age, and gender. Univariate and multivariate data analysis, the method of partial least squares-discriminant analysis (PLS-DA), were used. Register data on all synovial sarcomas were extracted for comparison. Results. The incidence of intra-articular synovial sarcomas was 3%. PLS-DA showed that age, effusion, size, and gender were the most important factors for discrimination between sarcomas and localized PVNS. No sarcomas were misclassified as PVNS with PLS-DA, while some PVNS were misclassified as sarcomas. Conclusions. The most important variables in differentiating i...Continue Reading

References

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Citations

Sep 21, 2018·Molecular and Clinical Oncology·Tomoki NakamuraAkihiro Sudo
May 10, 2020·BMC Musculoskeletal Disorders·Omar A Al-MohrejZayed S Al-Zayed
Dec 22, 2020·European Journal of Radiology·Syed Ehtasham JunaidAsif Saifuddin
Jan 21, 2021·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Qi CaoShengmei Zhou
Apr 10, 2021·Pediatric Radiology·Bardia Nadim, Jonathan D Samet

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Methods Mentioned

BETA
biopsies
amputation
biopsy

Software Mentioned

SIMCA
PLS
DA

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