PMID: 9429736Jan 16, 1998Paper

Intra-articular therapy in osteoarthritis

Baillière's Clinical Rheumatology
J Kirwan, E Rankin

Abstract

Although intra-articular therapy is widely used in the treatment of osteoarthritis (OA), those controlled clinical trials which include placebo groups suggest that there is little to be gained over joint aspiration alone, or even over a simple needle prick. Glucocorticoids may however offer a small additional symptom benefit over one or two weeks. Viscosupplementation may offer a slightly longer benefit. Intra-articular radiotherapy probably confers no benefit. Serious adverse effects are rare but local effects may occur in up to 10% of patients treated with viscosupplements. Future research should always include a placebo group in clinical studies, should clarify the possible benefits of viscosupplementation and should include in vitro work to consider the biological basis for possible actions of intra-articular therapy.

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Citations

Feb 28, 2006·International Orthopaedics·Suraj JoshyBinod Kumar Singh
Apr 15, 2004·Annals of the Rheumatic Diseases·L Gossec, M Dougados
Oct 11, 2015·Joint, Bone, Spine : Revue Du Rhumatisme·Christian Hubert Roux, Liana Euller-Ziegler
Jun 1, 2005·Reumatología clinica·F J Blanco, UNKNOWN Panel de Expertos de la Sociedad Española de Reumatología (SER)
Oct 4, 2015·The Journal of Arthroplasty·Nirav H AminGiles R Scuderi
Jan 1, 2006·Reumatología clinica·J Monfort, P Benito
Mar 27, 2009·Journal of Biomedical Materials Research. Part a·A BorzacchielloL Ambrosio
May 21, 2015·Drug Delivery and Translational Research·Taylor E KavanaughCraig L Duvall
Apr 21, 2006·The Cochrane Database of Systematic Reviews·N BellamyG Wells
Jul 5, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Luis Díaz-GallegoAna I Alvarez
Mar 1, 2005·Drugs & Aging·Marc Fajardo, Paul E Di Cesare
May 9, 2001·The Journal of Pharmacy and Pharmacology·M C Filion, N C Phillips
Dec 1, 2018·Nature Reviews. Rheumatology·Ian A JonesC Thomas Vangsness
Jan 1, 2013·International Journal of Chronic Diseases·Alexander MacDonald WoodAxel Weusten
Sep 30, 1999·Current Opinion in Rheumatology·P Creamer
Feb 25, 2006·The Journal of Bone and Joint Surgery. British Volume·A V PapavasiliouA Armitage
Mar 24, 2020·ACS Applied Materials & Interfaces·Ram SaraswatScott T Wood

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