Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival

Nature Cell Biology
Llewellyn J CoxSamie R Jaffrey

Abstract

During development of the nervous system, axons and growth cones contain mRNAs such as beta-actin, cofilin and RhoA, which are locally translated in response to guidance cues. Intra-axonal translation of these mRNAs results in local morphological responses; however, other functions of intra-axonal mRNA translation remain unknown. Here, we show that axons of developing mammalian neurons contain mRNA encoding the cAMP-responsive element (CRE)-binding protein (CREB). CREB is translated within axons in response to nerve growth factor (NGF) and is retrogradely trafficked to the cell body. In neurons that are selectively deficient in axonal CREB transcripts, increases in nuclear pCREB, CRE-mediated transcription and neuronal survival elicited by axonal application of NGF are abolished, indicating a signalling function for axonally synthesized CREB. These studies identify a signalling role for axonally derived CREB, and indicate that signal-dependent synthesis and retrograde trafficking of transcription factors enables specific transcriptional responses to signalling events at distal axons.

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R B Campenot
Jan 13, 1998·Journal of Neurocytology·J X TongK M Rich
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·P CrinoJ Eberwine
Sep 7, 2001·Nature Neuroscience·F L WatsonR A Segal
Feb 5, 2003·Biochemical and Biophysical Research Communications·Haruhisa HiguchiMasaya Tohyama
Apr 30, 2003·Neuron·Ian TietjenCatherine Dulac
Jul 11, 2003·Journal of Neurophysiology·Andreas JerominDaniel Johnston
Aug 30, 2003·Nature Neuroscience·Mollie K MeffertDavid Baltimore
Dec 23, 2003·Neuron·Shlomit HanzMike Fainzilber
Feb 21, 2004·Science·Jonathan R Terman, Alex L Kolodkin
Sep 1, 2004·Cellular Signalling·Mona JohannessenUgo Moens
Sep 8, 2004·Trends in Cell Biology·David S GoldfarbStephen A Adam
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Michael Piper, Christine Holt
Feb 4, 2005·Nature·Joel D Richter, Nahum Sonenberg
Feb 22, 2005·Current Opinion in Neurobiology·Charles L Howe, William C Mobley
Mar 23, 2005·Current Opinion in Cell Biology·Daniela HoellerIvan Dikic
Aug 3, 2005·Nature Reviews. Neuroscience·Larry S ZweifelDavid D Ginty
Aug 19, 2005·Nature·Karen Y WuSamie R Jaffrey
Nov 8, 2005·Science·Brenda L Bloodgood, Bernardo L Sabatini
Mar 22, 2006·Nature Biotechnology·Nadya G GurskayaKonstantin A Lukyanov
May 26, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ulrich HengstSamie R Jaffrey
Nov 7, 2006·Trends in Biochemical Sciences·Kevin Czaplinski, Robert H Singer
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Bianxiao CuiSteven Chu

❮ Previous
Next ❯

Citations

Mar 20, 2010·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Martin MiklMichael A Kiebler
Mar 27, 2013·Pflügers Archiv : European journal of physiology·P ZamburlinDavide Lovisolo
Feb 5, 2008·Nature Cell Biology·Andrew C Lin, Christine E Holt
Oct 12, 2010·Nature Neuroscience·Freddy JeanneteauMoses V Chao
Aug 22, 2009·Nature Reviews. Molecular Cell Biology·Alexander Sorkin, Mark von Zastrow
Apr 14, 2012·Nature Reviews. Neuroscience·Hosung JungChristine E Holt
Apr 11, 2009·Journal de la Société de biologie·Alain Trembleau
Oct 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kwok-On LaiKelsey C Martin
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Martín RofféGlaucia Noeli Maroso Hajj
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Michael S CohenSamie R Jaffrey
Jan 23, 2009·The Journal of Biological Chemistry·Mariano BisbalAlfredo Cáceres
Feb 20, 2010·Molecular & Cellular Proteomics : MCP·Dianna E Willis, Jeffery L Twiss
Jul 10, 2012·Open Biology·Alessia Deglincerti, Samie R Jaffrey
Dec 8, 2009·Science·Christine E Holt, Simon L Bullock
Nov 22, 2012·Neural Development·Melissa M Langworthy, Bruce Appel
Aug 23, 2012·Development·Caroline MedioniFlorence Besse
May 11, 2012·Journal of Cell Science·Rebecca B SmithGuillermo Marqués
Sep 21, 2011·PloS One·Randi StewartRebecca Berdeaux
Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kristy Welshhans, Gary J Bassell
Oct 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Breset A WalkerSamie R Jaffrey
Dec 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mirela SpillaneGianluca Gallo
Feb 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher J DonnellyJeffery L Twiss
Jul 19, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christina TimmermanSubhabrata Sanyal
Nov 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Krishna H ZivrajChristine E Holt
Apr 26, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amar N KarBarry B Kaplan
Oct 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dianna E WillisJeffery L Twiss
Nov 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Armaz AschrafiBarry B Kaplan
Jan 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Florence K RochePaul C Letourneau
Feb 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sean B ChristieJustin R Fallon
Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ohannes K MelemedjianTheodore J Price
Jan 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stéphane NédelecHynek Wichterle
Mar 29, 2014·Nature Communications·Neilia G GraciasUlrich Hengst
Mar 13, 2012·Annual Review of Physical Chemistry·Praveen D ChowdaryBianxiao Cui
Aug 13, 2011·Cellular and Molecular Life Sciences : CMLS·N F M Olde LoohuisA Aschrafi
Oct 11, 2016·Current Genetic Medicine Reports·Lulu I T KorsakMichael R Akins
Jan 20, 2010·The Journal of Cell Biology·Armela JosetMartin E Schwab
Sep 12, 2015·The Journal of Comparative Neurology·Katrin B GehringDorothea Eisenhardt
Oct 1, 2015·Genes, Brain, and Behavior·D E Ehrlich, S A Josselyn
May 3, 2011·Current Opinion in Genetics & Development·Sharon A Swanger, Gary J Bassell
May 3, 2011·Current Opinion in Genetics & Development·Hosung JungChristine E Holt
May 31, 2011·Progress in Neurobiology·Michelle R Lyons, Anne E West
Nov 27, 2010·Gene Expression Patterns : GEP·Yaiza BelacortuNuria Paricio
Jul 16, 2010·Trends in Cell Biology·Derrick Gibbings, Olivier Voinnet
Dec 17, 2009·Progress in Neurobiology·Annica B Dahlstrom

❮ Previous
Next ❯

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