PMID: 15371916Sep 17, 2004Paper

Intra-epithelial T cells in coeliac disease

European Journal of Gastroenterology & Hepatology
R G Peter Watson, Simon D Johnston

Abstract

Coeliac disease is an enteropathy associated with dietary gluten which occurs in individuals with a genetic predisposition. The pathogenesis remains obscure although it is clear that only certain parts of the gliadin molecule are toxic and there is considerable evidence of immunological activity, including antibody production. In this issue of European Journal of Gastroenterology and Hepatology Carton et al. present evidence in favour of an inherent depletion of CD4CD8 T cells, which could result in a loss of oral tolerance to ingested gliadin. Using flow cytometry they also demonstrated that the classic T-cell infiltration of coeliac disease is not due to an increase in T cells but is an apparent increase associated with a relative decrease in enterocytes as a result of the change in architecture of the mucosa. These could be important fundamental observations in helping to unravel the pathogenesis of coeliac disease.

Citations

Oct 5, 2007·International Journal of Surgical Pathology·Ricardo Drut, Eduardo Cueto Rúa
Mar 17, 2007·Clinical and Experimental Immunology·M I TorresA Ríos
Mar 30, 2006·International Immunology·M I TorresA Ríos

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