PMID: 2109973Mar 1, 1990Paper

Intra-habenular injection of 6-hydroxydopamine produces impaired acquisition of DRL operant behavior

Behavioral and Neural Biology
E W ThorntonR McClelland

Abstract

The anatomical connections of the habenula complex indicate it provides a relay between limbic forebrain and midbrain. Somewhat paradoxically, consequences of nonspecific lesion of the habenula are ambiguous with little change in basic response evident within simple behavioral paradigms. However, the potential functional importance for this relay has more recently been indicated by the demonstration of deficits in the ability of lesioned animals to alter behavior appropriate to both internal and external stimuli in more demanding behavioral tasks. Doubts concerning the importance of the habenula remain because of the large number of descending fibers of passage through the habenula. To provide more substantive evidence, 6-hydroxydopamine was injected into the habenula of rats to provide more limited lesion of catecholaminergic terminals. Animals were subsequently trained on an operant DRL 20-s schedule for which deficits have been reported following nonspecific lesion of the habenula. Lesioned animals showed a tendency to overrespond and were significantly less efficient on the schedule with decreased number of reinforcements received relative to controls. While the neurotoxic lesion procedure used does not differentiate noradr...Continue Reading

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Citations

Jun 23, 2009·Neuroscience Letters·Yuhong WangWenhua Zhou
Jul 1, 1997·Neurobiology of Learning and Memory·A Vale-MartínezI Morgado-Bernal
Dec 10, 1999·Brain and Cognition·F H Previc
Jul 14, 2010·Neuron·Ethan S Bromberg-MartinOkihide Hikosaka
Dec 7, 2018·International Journal of Radiation Biology·Abdelrazek B AbdelrazzakBasma F Elnady
Dec 1, 1991·The International Journal of Neuroscience·R Sandyk

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