Intra-individual head-to-head comparison of Sirolimus®- and Paclitaxel®-eluting stents for coronary revascularization. A randomized, multi-center trial

International Journal of Cardiology
M KollumFreRace Trial Investigators

Abstract

Despite the known effects of drug-eluting stents (DES), other cofactors attributed to patient characteristics affect their success. Interest focused on designing a study minimizing these factors to answer continuing concerns on the heterogeneity of response to different DESs. The study's aim was to investigate the feasibility and impact of an intra-individual comparison design in patients (pts) with two coronary artery stenosis treated with a Sirolimus- (SES) and a Paclitaxel- (PES) eluting stent. The study was conducted as a prospective, randomized, multi-center trial in 112 pts who consented to treatment with a SES and a PES. Pts were eligible if they suffered from the presence of two single primary target lesions in two different native coronary arteries. Lesions were randomized to either SES or PES treatment. The primary endpoint was in-stent luminal late loss (LLL), as determined by quantitative angiography at 8 months; clinical follow up was obtained at 1, 8, and 12 months additionally. The LLL (0.13 ± 0.28 mm SES vs. 0.26 ± 0.35 mm PES, p=0.011) showed less neointima in SES. With a predefined cut-off criterion of 0.2mm difference in LLL, 53/87 pts SES and PES were similar effective. 34/87 pts had a divergent result, 26 p...Continue Reading

References

Aug 1, 1989·Circulation·E Braunwald
Jul 25, 2003·Cancer Biology & Therapy·Shile HuangPeter J Houghton
Oct 3, 2003·The New England Journal of Medicine·Jeffrey W MosesUNKNOWN SIRIUS Investigators
Jan 13, 2005·JAMA : the Journal of the American Medical Association·Adnan KastratiUNKNOWN ISAR-DESIRE Study Investigators
Jan 18, 2005·Journal of the American College of Cardiology·Jean-Jacques GoyCharles Seydoux
Aug 18, 2005·The New England Journal of Medicine·Stephan WindeckerBernhard Meier
Aug 18, 2005·The New England Journal of Medicine·Alban DibraUNKNOWN ISAR-DIABETES Study Investigators
Sep 15, 2005·JAMA : the Journal of the American Medical Association·Gregg W StoneUNKNOWN TAXUS V Investigators
Oct 20, 2005·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Alan Richardson, Stan B Kaye
Jan 13, 2006·European Heart Journal·Julinda MehilliUNKNOWN Intracoronary Drug-Eluting Stenting to Abrogate Restenosis in Small Arteries (ISAR-SMART 3) Study Investigators
Feb 24, 2006·JAMA : the Journal of the American Medical Association·Marie-Claude MoriceUNKNOWN REALITY Trial Investigators
Jul 4, 2006·Journal of the American College of Cardiology·Michael JonerRenu Virmani
Jan 9, 2007·Journal of the American College of Cardiology·Pascal MeierChristian Seiler
Feb 14, 2007·The New England Journal of Medicine·Laura MauriDonald E Cutlip
Feb 14, 2007·The New England Journal of Medicine·Bo LagerqvistUNKNOWN SCAAR Study Group
Feb 14, 2007·The New England Journal of Medicine·Adnan KastratiAlbert Schömig
Feb 14, 2007·The New England Journal of Medicine·Gregg W StoneMartin B Leon
Oct 5, 2007·The New England Journal of Medicine·Jack V TuRon Goeree
Oct 30, 2007·Circulation·Stephan Windecker, Bernhard Meier
May 31, 2008·Journal of the American College of Cardiology·Michalis I HamilosUNKNOWN NOBORI CORE Investigators
Jul 26, 2008·Journal of the American College of Cardiology·Michael JonerRenu Virmani
Aug 23, 2008·Journal of the American College of Cardiology·Seung-Whan LeeSeung-Jung Park
Oct 23, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Jung-Sun KimUNKNOWN Korean Multicenter Angioplasty Team (KOMATE) Investigators
Oct 25, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Charles ChanUNKNOWN DECODE Investigators

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Citations

Dec 20, 2013·International Journal of Molecular Sciences·Carlos M CamposPatrick W Serruys
Aug 12, 2016·Circulation. Cardiovascular Interventions·Salvatore CasseseAdnan Kastrati
Aug 12, 2016·Circulation. Cardiovascular Interventions·John A Ormiston, Mark W I Webster

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