Intra-individual variability of high-sensitivity C-reactive protein: age-related variations over time in Japanese subjects

Circulation Journal : Official Journal of the Japanese Circulation Society
Ali NasermoaddeliSadanobu Kagamimori

Abstract

Prospective studies have demonstrated a direct association between the baseline level of high-sensitivity C-reactive protein (hsCRP) and the risk of developing cardiovascular disease. The potential for hsCRP variability during the follow-up interval is of great interest, so the repeatability of measurements of hsCRP in men and women, and in different age groups, was investigated in the present study. The measurement of hsCRP was performed in 899 male and 780 female Japanese civil servants aged 18-60 years in the spring of 2004 and 2005. Within-subject repeatability and intra-class correlation coefficient of reliability were used to characterize the variation in measurements. Error of the measurement process was negligible, as the analytical variance was 0.0003 [ln(mg/L)] [ln(mg/L)] with a reliability coefficient of 0.997. In contrast, the within-subject variation of hsCRP was considerable with a reliability coefficient of 0.61 in both sexes and repeatability coefficients of 5.25 and 5.38 in men and women, respectively. The variation differed with age, especially in women, as less variation was observed in subjects over 40 years of age during the follow-up interval. The results suggest that a single measurement of hsCRP is subje...Continue Reading

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Citations

Feb 20, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Eiji Oda, Ryu Kawai
May 20, 2014·Cancer Causes & Control : CCC·Sheetal HardikarEmily White
Feb 6, 2010·Cancer Causes & Control : CCC·Elizabeth A PlatzAlan R Kristal
May 17, 2014·Acta Psychiatrica Scandinavica·S L van OckenburgJ G M Rosmalen
Apr 30, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Barbara SwansonKimberly A Snell
Jun 4, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Eiji Oda, Ryu Kawai
Mar 2, 2011·Nature Reviews. Nephrology·Christiaan L MeuweseJuan J Carrero
Dec 2, 2020·Journal of Clinical Periodontology·Fernando Oliveira CostaLuís Otávio Miranda Cota
May 9, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sandi L NavarroJohanna W Lampe

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