Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation

World Journal of Transplantation
Siddharth NarayananAppakalai N Balamurugan

Abstract

The intra-islet microvasculature is a critical interface between the blood and islet endocrine cells governing a number of cellular and pathophysiological processes associated with the pancreatic tissue. A growing body of evidence indicates a strong functional and physical interdependency of β-cells with endothelial cells (ECs), the building blocks of islet microvasculature. Intra-islet ECs, actively regulate vascular permeability and appear to play a role in fine-tuning blood glucose sensing and regulation. These cells also tend to behave as "guardians", controlling the expression and movement of a number of important immune mediators, thereby strongly contributing to the physiology of islets. This review will focus on the molecular signalling and crosstalk between the intra-islet ECs and β-cells and how their relationship can be a potential target for intervention strategies in islet pathology and islet transplantation.

Citations

Mar 27, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Mingming LiuRuijuan Xiu
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BETA
glycosylation

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