Intra-observer and inter-observer variability in two grading systems for oral epithelial dysplasia: A multi-centre study in India

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Kannan RanganathanSaman Warnakulasuriya

Abstract

The presence and grading of oral epithelial dysplasia (OED) are considered the gold standard for predicting the malignant risk of oral potentially malignant disorders. However, inter-observer and intra-observer agreement in the context of reporting on OED grading has been reputedly considered unreliable. We undertook a multi-centre study of six Indian oral pathologists to assess variations in reporting OED using the World Health Organization (WHO; 2005) system and also the recently introduced binary system. The observer variability was assessed with the use of kappa statistics. The weighted kappa intra-observer agreement scores improved (κw  = 0.5012) on grouping by two grades as no and mild dysplasia versus moderate and severe dysplasia compared to binary grading system (κ = 0.1563) and WHO grading system (κw  = 0.4297). Poor to fair inter-observer agreement scores were seen between the principal investigator (PI) and the other five observers using the WHO grading system (κ = 0.051-0.231; κw  = 0.145 to 0.361; 35% to 46%) and binary grading system (κ = 0.049 to 0.326; 50 to 65%). There is considerable room for improvement in the assessment of OED using either system to help in standardised reporting. The professional pathology...Continue Reading

References

Oct 1, 1985·Journal of Oral Pathology·J J PindborgP Holmstrup
May 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A KarabulutE Dabelsteen
Feb 25, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·L M AbbeyD J Krutchkoff
Jul 6, 2001·The Journal of Pathology·S Warnakulasuriya
May 24, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Jesper Reibel
Jul 9, 2003·Community Dentistry and Oral Epidemiology·D J BrothwellJ L Leake
Jan 15, 2004·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Dena J FischerStephen M Schwartz
Feb 7, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S WarnakulasuriyaE Dabelsteen
May 21, 2009·Head & Neck·Hisham M MehannaChristopher C McConkey
Sep 1, 2007·Head and Neck Pathology·Paul M Speight
Dec 12, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Paul NankivellHisham Mehanna
Jan 7, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·F DostC S Farah
Feb 18, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Paul C Edwards
Jul 29, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Paul M SpeightJohn T McDevitt
Sep 8, 2016·Journal of Oral and Maxillofacial Pathology : JOMFP·Lakshmi KrishnanArchana Patil
Feb 6, 2018·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Paul M SpeightOmar Kujan
May 16, 2019·Periodontology 2000·Wanninayake M TilakaratneRohana Kumara De Silva

❮ Previous
Next ❯

Citations

Mar 18, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Majdy IdreesOmar Kujan
Apr 5, 2021·Oral Diseases·Bubacar EmbalóElena Riet Correa Rivero
Mar 3, 2021·The Journal of Clinical Investigation·Can F KoyuncuAnant Madabhushi
Aug 8, 2021·Cancers·Caroline McCarthyRichard J Shaw
Jul 27, 2021·Pest Management Science·Seth J DormanAnders S Huseth
Aug 22, 2021·Oral Diseases·Edward OdellPhilip Sloan
Nov 20, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Hans Prakash SathasivamMax Robinson
Jan 8, 2022·International Journal of Surgical Pathology·Zaid H KhouryAhmed S Sultan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Oral and Maxillofacial Pathology : JOMFP
K M GeethaJ Saleha
European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Flora YanTerry A Day
Journal of Oral and Maxillofacial Pathology : JOMFP
Lakshmi KrishnanArchana Patil
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
F DostCamile S Farah
© 2022 Meta ULC. All rights reserved