PMID: 8938541Nov 1, 1996Paper

Intra-observer and inter-observer variation in the histopathological assessment of chronic viral hepatitis

Journal of Hepatology
R D GoldinN Patel

Abstract

The way in which liver biopsies showing chronic hepatitis are reported is undergoing re-evaluation. A related question is how the inflammatory and fibrotic changes in these liver biopsies can be semi-quantitatively assessed so that comparisons can be made between groups of patients and the effect of treatment on disease progression studied. We have carried out a blinded trial in which 20 cases of chronic viral hepatitis were assessed by five histopathologists, using the Knodell and Scheuer scoring systems (two of the most commonly used systems), on two separate occasions. The results were analysed using Kappa statistics, and also by seeing for how many slides the pathologists showed no significant disagreement. While both systems produced good inter- and intra-observer variation when fibrosis was assessed the Scheuer system produced slightly higher Kappa values. The Scheuer system produced considerably better agreement when the severity of inflammation was examined. A multirater kappa analysis confirmed that both systems showed better agreement for fibrosis scores than for inflammation scores. We conclude that, while both systems produced reasonable agreement, this was greater using the Scheuer system. When any new scoring syst...Continue Reading

References

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Citations

Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N C TassopoulosD F Gray
Jun 10, 2009·Gastroentérologie Clinique Et Biologique·UNKNOWN l'Association Française pour l'Etude du Foie
Jan 28, 2003·Journal of Hepatology·Rekha Rozario, Banumathi Ramakrishna
Jan 28, 2003·Journal of Hepatology·Peter J Scheuer
Jan 8, 2004·Journal of Hepatology·Valeer J Desmet
May 25, 2002·Liver·L Martin LaggingGunnar Norkrans
Apr 11, 2003·Pathology International·Miyuki NakajiMasato Kasuga
Mar 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mark S Sulkowski, David L Thomas
Jul 30, 2009·Journal of Gastroenterology and Hepatology·Alice Unah Lee
Aug 7, 2008·Journal of Addictive Diseases·David L Thomas, Mark S Sulkowski
May 19, 2006·American Journal of Clinical Pathology·Evangelos CholongitasAndrew Kenneth Burroughs
Mar 27, 2010·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Faisal M Sanai, Emmet B Keeffe
Mar 27, 2010·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Khalid A AlswatWasim Jafri
Nov 22, 2012·Radiology·Vanja VarenikaBenjamin M Yeh
Feb 26, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L BaiocchiG Tisone
Sep 11, 2004·Haemophilia : the Official Journal of the World Federation of Hemophilia·D TheodoreL M Aledort
May 15, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·E CholongitasA K Burroughs
Jul 15, 2015·Scandinavian Journal of Gastroenterology·András RókuszPéter Nagy
Nov 28, 2001·The American Journal of Gastroenterology·P A BejaranoK E Sherman
Jun 24, 2008·Human Pathology·Dorothée Bouron-Dal SoglioJean-Christophe Fournet
Apr 4, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Cheng FangPaul S Sidhu
Jun 8, 2004·The American Journal of Gastroenterology·Nezam H Afdhal, David Nunes
Sep 14, 1999·The American Journal of Gastroenterology·E M BruntB R Bacon
Mar 25, 2017·American Journal of Clinical Pathology·Michael PavlidesLai Mun Wang
Dec 13, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Brigitta GlobkeDennis Eurich

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