PMID: 11321190Apr 26, 2001Paper

Intra-observer, inter-observer and inter-scanner variations in brain MRI volume measurements in multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
C GasperiniM Filippi

Abstract

Measurement of brain volume on magnetic resonance imaging (MRI) scans is regarded as an objective marker of multiple sclerosis (MS) severity with the potential to monitor treatment efficacy accurately. This study was performed to assess the variability of brain MRI volume measurements. We studied nine patients with relapsing-remitting MS, who were imaged on two occasions (separated by an interval of 24 h) using two different MR scanners and fast fluid-attenuated inversion recovery (fast-FLAIR) sequences. The whole brain volume computed from each image was measured three times by three observers using a seed-growing technique based on signal intensity thresholding. Intra-observer, inter-observer and inter-scanner variabilities were expressed as coefficients of variations (COVs). The inter-scanner variability included not only the intra-observer variation but also the repositioning variability and the variation in observed brain volume caused by different scanner hardware and sequence implementations. There was no statistically significant difference in patients' brain volume values between observers (P=0.82) or between scanners (P=0.30). The mean intra-observer COV was 1.2% (s.e.=0.4%), the mean inter-observer COV was 1.8% (s.e....Continue Reading

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Citations

Nov 11, 2003·Journal of the Neurological Sciences·M A HorsfieldR Bakshi
Dec 13, 2005·Journal of Neurovirology·Francesca BagnatoSteven Jacobson
Feb 1, 2013·Brain : a Journal of Neurology·Tarunya ArunJacqueline Palace
May 2, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Miriam Jocelyn RodriguezRanjan Duara
Dec 11, 2008·Neuroimaging Clinics of North America·Robert A BermelJeffrey A Cohen
Apr 9, 2008·NeuroImage·Tim B DyrbyUNKNOWN LADIS study group
Jun 15, 2016·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Amal P R SamaraweeraNikos Evangelou
Apr 28, 2007·Multiple Sclerosis : Clinical and Laboratory Research·S SchachL Kappos
Dec 31, 2005·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Rohit BakshiRobert A Bermel
Apr 6, 2006·Journal of Magnetic Resonance Imaging : JMRI·Valerie M AndersonDavid H Miller
Oct 5, 2013·Medicine and Science in Sports and Exercise·Maryse FortinMichele C Battié
Nov 25, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Edward Brian WelchClifford R Jack

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