Intra-operative high-resolution mapping of slow wave propagation in the human jejunum: Feasibility and initial results

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
T R AngeliL K Cheng

Abstract

Bioelectrical slow waves are a coordinating mechanism of small intestine motility, but extracellular human studies have been restricted to a limited number of sparse electrode recordings. High-resolution (HR) mapping has offered substantial insights into spatiotemporal intestinal slow wave dynamics, but has been limited to animal studies to date. This study aimed to translate intra-operative HR mapping to define pacemaking and conduction profiles in the human small intestine. Immediately following laparotomy, flexible-printed-circuit arrays were applied around the serosa of the proximal jejunum (128-256 electrodes; 4-5.2 mm spacing; 28-59 cm2 ). Slow wave propagation patterns were mapped, and frequencies, amplitudes, downstroke widths, and velocities were calculated. Pacemaking and propagation patterns were defined. Analysis comprised nine patients with mean recording duration of 7.6 ± 2.8 minutes. Slow waves occurred at a frequency of 9.8 ± 0.4 cpm, amplitude 0.3 ± 0.04 mV, downstroke width 0.5 ± 0.1 seconds, and with faster circumferential velocity than longitudinal (10.1 ± 0.8 vs 9.0 ± 0.7 mm/s; P = .001). Focal pacemakers were identified and mapped (n = 4; mean frequency 9.9 ± 0.2 cpm). Disordered slow wave propagation was ...Continue Reading

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Citations

Nov 20, 2018·Neuromodulation : Journal of the International Neuromodulation Society·James A PenfoldGregory O'Grady
Mar 6, 2019·Experimental Physiology·Jan D Huizinga, Sean P Parsons
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Apr 23, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yi LiuJiande Chen
Aug 7, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anthony C JohnsonBeverley Greenwood-Van Meerveld
Jun 30, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Ashley Cherian AbrahamNiranchan Paskaranandavadivel
Jan 26, 2020·Annals of Biomedical Engineering·Abhishek A KamatTimothy R Angeli
Dec 5, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Daniel A CarsonChristopher N Andrews
Jan 21, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Zahra AghababaieTimothy R Angeli-Gordon

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