Intra-Operative Neural Monitoring of Thyroid Surgery in a Porcine Model

Journal of Visualized Experiments : JoVE
Che-Wei WuI-Cheng Lu

Abstract

Intraoperative injury to the recurrent laryngeal nerve (RLN) can cause vocal cord paralysis, which interferes with speech and can potentially interfere with breathing. In recent years, intraoperative neural monitoring (IONM) has been widely adapted as an adjunct technique to localize the RLN, detect RLN injury, and predict vocal cord function during the operations. Many studies have also used animal models to investigate new applications of IONM technology and to develop reliable strategies for preventing intraoperative RLN injury. The aim of this article is to introduce a standard protocol for using a porcine model in IONM research. The article demonstrates the procedures for inducing general anesthesia, performing tracheal intubation, and experimental design to investigate the electrophysiological characteristics of RLN injuries. Applications of this protocol can improve overall efficacy in implementing the 3R principle (replacement, reduction and refinement) in porcine IONM studies.

Citations

Mar 11, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Daqi ZhangGianlorenzo Dionigi
Jun 17, 2020·The Laryngoscope·Tzu-Yen HuangChe-Wei Wu
Aug 15, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·I-Cheng LuChe-Wei Wu

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