Intra-operative tumour detection and staging in colorectal cancer surgery.

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
J P TiernanD G Jayne

Abstract

Surgical resection for colorectal cancer involves segmental resection and regional lymphadenectomy. The appropriateness of this 'one-size-fits-all' strategy is questioned as bowel cancer screening programmes result in a shift to earlier stage disease. Currently, the nodal status of a colorectal cancer can only be reliably determined by histopathological examination of the resected specimen. New methods of intra-operative staging are required to allow surgical resection to be tailored to the stage of the disease. A literature search was performed of PubMed and Embase databases using the terms 'colon' OR 'colorectal' AND 'intra-operative detection' OR 'intra-operative staging' OR 'intra-operative detection' OR 'radioimmunoguided surgery'. Articles published between January 1980 and January 2012 were included. Technologies that have the potential to allow intra-operative staging and treatment stratification were identified and further searches performed. Established techniques such as sentinel lymph node mapping and radioimmunoguided surgery have benefited from combination with other technologies to allow real-time intra-operative staging. Intra-operative fluorescence, using naturally fluorescent biomarkers or fluorescent tumour p...Continue Reading

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Citations

Feb 12, 2014·Techniques in Coloproctology·A BhanguP Tekkis
Aug 25, 2015·Medical Engineering & Physics·J H ChandlerA Neville
Mar 30, 2016·World Journal of Gastrointestinal Surgery·Mark L H Ong, John B Schofield
Jan 17, 2013·British Journal of Cancer·J P TiernanT A Hughes
Dec 30, 2016·Physiological Measurement·J H ChandlerP R Culmer
Dec 30, 2020·Cancers·Ruben D HouvastCornelis F M Sier
Dec 17, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Francesco CollamatiRiccardo Faccini

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