Intra-pituitary regulation of gonadotrophs in male rodents and primates

Reproduction : the Official Journal of the Society for the Study of Fertility
S J Winters, Joseph P Moore

Abstract

Paracrine and autocrine regulation is well established in many organs including the gonads, but the notion of communication among pituitary cells is a relatively new concept. The FSH-beta and GnRH-receptor genes are up-regulated by pituitary activin and down-regulated by pituitary follistatin, and circulating inhibin disrupts this local regulation by functioning as an endogenous competitor of the activin receptor. Activin and follistatin production by folliculostellate cells may play a central role in these responses. alpha-Subunit expression is maintained at high levels in the absence of GnRH through unknown mechanisms. There is evidence that the intra-pituitary regulation of FSH-beta and GnRH-receptor gene expression may activate pubertal maturation in male rats. Finally, there are marked differences in follistatin expression and its regulation by GnRH and androgens in male primates and rats that appear to explain species differences in the differential secretion of FSH and LH, although the physiological significance of these differences is not yet known.

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Citations

May 27, 2005·Biology of Reproduction·Pei SuWilliam L Miller
Jun 1, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·M A AragónR Domínguez
Feb 15, 2012·Molecular and Cellular Endocrinology·Louise M BilezikjianWylie W Vale
Apr 21, 2010·Fertility and Sterility·Daniel J BernardPankaj Lamba
Apr 1, 2016·Scientific Reports·Ghislaine GarrelJoëlle Cohen-Tannoudji
Jan 24, 2013·Critical Reviews in Biochemistry and Molecular Biology·Wenhui SuC Yan Cheng
Jan 17, 2015·Annales d'endocrinologie·Mawussi AdjaklyDominique Bernard-Gallon
Mar 24, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Nataša NestorovićVerica Milošević
Feb 3, 2012·Physiological Reviews·Carolina Perez-CastroEduardo Arzt
Dec 19, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jo Ann JanovickP Michael Conn
May 11, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Haiqi ChenC Yan Cheng
Oct 29, 2018·Neuroendocrinology·Ghislaine GarrelJoëlle Cohen-Tannoudji

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