PMID: 11920517Mar 29, 2002Paper

Intra-tumoral interleukin-6 down-regulation system and genetic mutations of tumor suppressor genes in colorectal carcinoma

Cancer
C MikiMasato Kusunoki

Abstract

The interleukin (IL)-1-IL-6 network, the most potent cascade of pro-inflammatory cytokines, plays an autocrine role in tumor growth. The IL-1-IL-6 network is down-regulated by a phased cytokine inhibitor IL-1 receptor antagonist (ra) and an anti-inflammatory cytokine IL-10. The current study evaluated this down-regulation system in colorectal carcinoma and its relation to the genetic alteration of tumor suppressor genes. Seventy-four specimens of primary colorectal carcinoma and normal mucosa were collected to measure tissue concentrations of cytokines. Polymerase chain reaction amplification was performed to investigate the loss of heterozygosity of the microsatellite markers on chromosomes 17p and 18q. The IL-1ra/IL-6 ratio in the carcinoma specimens was lower than ratios in adenomas and normal mucosae and decreased with disease progression. The IL-1ra/IL-6 ratio in early cancers tended to be lower than that in adenomas and normal mucosae. However, the tissue concentrations of IL-1beta and IL-10 were not associated with any clinicopathologic parameters. The tissue IL-1ra concentration correlated with that of IL-6 only in adenomas and early cancers. Immunohistochemically, IL-1ra and IL-6 were localized in the tumor cytoplasm. ...Continue Reading

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Citations

May 20, 2005·Clinical Oncology : a Journal of the Royal College of Radiologists·C MikiM Kusunoki
Sep 2, 2011·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Hidefumi KitaTomoyuki Goya
Dec 29, 2006·Journal of Surgical Oncology·Chikao MikiMasato Kusunoki
Jan 31, 2006·Cancer Letters·Farideh EsfandiGholam Basati
May 27, 2014·Pathology Oncology Research : POR·Guanglin CuiJon Florholmen
Apr 29, 2009·Journal of Orthopaedic Surgery·C UchikawaK Takagishi

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