Intra-uterine insemination with prepared sperm vs. unprepared first split ejaculates. A randomized study

M GoldenbergR Weissenberg


In this randomized prospective study, we determined the conception rate following intra-uterine insemination with washed and prepared sperm, or with the first portion of a split ejaculate, in couples with longstanding male (n = 27, 70 treatment cycles) or cervical infertility (n = 14, 29 treatment cycles). Folliculogenesis and ovulation were induced by human menopausal gonadotropin and human chorionic gonadotropin. Significantly more couples conceived in the male infertility group following intra-uterine insemination with washed sperm, than after intra-uterine insemination with split ejaculate (9 vs. 2; P less than 0.05), while no difference in pregnancy rate (2 vs. 2) was found by the two intra-uterine insemination methods in the cervical infertility group.


Oct 19, 2007·The Cochrane Database of Systematic Reviews·C M BoomsmaC Farquhar
Oct 16, 2019·The Cochrane Database of Systematic Reviews·Carolien M BoomsmaCindy Farquhar
Apr 15, 2020·Scientific Reports·Samyra SiqueiraLuiz Francisco Baccaro
Sep 1, 2017·Human Reproduction·L LemmensDutch Foundation for Quality Assessment in Medical Laboratories

Related Concepts

Cell Separation
Subfertility, Female
Subfertility, Male
Insemination, Artificial, Homologous
Y-Chromosome-Bearing Sperm

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