Intraaccumbens administration of NMDA receptor antagonist (+/-)-CPP prevents locomotor activation conditioned by morphine and amphetamine in rats

Pharmacology, Biochemistry, and Behavior
A Iu Bespalov, E E Zvartau

Abstract

In the present experiments the influence of NMDA receptor antagonist (+/-)-CPP on morphine- and amphetamine-conditioned activation of locomotor activity was studied in rats chronically implanted with bilateral cannulas in the nucleus accumbens septi. Animals were conditioned by pairing subcutaneous injections of morphine (3.0 mg/kg), amphetamine (1.5 mg/kg), or saline with a distinctive environment. Following the five drug-environment pairings, rats displayed significant increase in locomotion when exposed to the drug-paired environment. The expression of this conditioned response was completely prevented by the bilateral intraaccumbens pretreatment with (+/-)-CPP (1.0, but not 0.1 or 0.3 microgram/ microliter/side). These findings suggest that the locomotor hyperactivity conditioned by morphine and amphetamine involves the activation of NMDA receptors within the nucleus accumbens.

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Citations

May 20, 1997·European Journal of Pharmacology·A Bespalov, E Zvartau
Mar 10, 2000·European Journal of Pharmacology·A Y BespalovR L Balster
Jun 7, 2007·Behavioural Pharmacology·Mohammad-Reza ZarrindastAkbar Hajizadeh-Moghaddam
Dec 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Haosheng SunEric J Nestler
Mar 25, 2016·Canadian Journal of Physiology and Pharmacology·Arya Haj-MirzaianAhmadReza Dehpour
Nov 19, 2003·Journal of Neurochemistry·Joshua T DudmanChristine Konradi
Sep 17, 2014·Neurobiology of Learning and Memory·Yasaman AlaghbandJohn F Marshall
Apr 15, 2014·European Journal of Pharmacology·Arya Haj-MirzaianShahram Ejtemaei Mehr

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