Intraamniotic interleukin-1 accelerates surfactant protein synthesis in fetal rabbits and improves lung stability after premature birth

The Journal of Clinical Investigation
K BryM Hallman

Abstract

Intraamniotic infection is associated with increased IL-1 activity in amniotic fluid, increased incidence of preterm labor, and with decreased incidence of respiratory distress syndrome in infants born prematurely. We hypothesized that an elevated IL-1 in amniotic fluid promotes fetal lung maturation. On day 23 or 25 of gestation (term 31 d), either IL-1alpha (150 or 1,500 ng per fetus) or its antagonist IL-1 receptor antagonist (IL-1ra, 20 microg) was injected to the amniotic fluid sacs in one uterine horn, whereas the contralateral amniotic sacs were injected with vehicle. Within 40 h, IL-1alpha caused a dose-dependent increase in surfactant protein-A (SP-A) and SP-B mRNAs (maximally, fivefold), without affecting lung growth or increasing inflammatory cells in the lung. Both genders, and upper and lower lung lobes were similarly affected. IL-1ra did not modify SP-A, -B, or -C mRNA. IL-1 increased the intensity of staining of alveolar type II cells for SP-B, and the concentrations of SP-B, -A, and disaturated phosphatidylcholine in bronchoalveolar lavage. The dynamic lung compliance and the postventilatory expansion of lungs were increased two- to fourfold after IL-1alpha treatment. In fetal lung explants, IL-1alpha increased ...Continue Reading

References

Apr 1, 1992·American Journal of Reproductive Immunology : AJRI·R RomeroC A Dinarello
Jun 1, 1992·Immunological Reviews·C A Dinarello
Feb 12, 1992·Biochimica Et Biophysica Acta·J A WhitsettM A O'Reilly
May 1, 1992·American Journal of Obstetrics and Gynecology·R RomeroJ Williams
Nov 1, 1991·The Journal of Clinical Investigation·W P Arend
Apr 1, 1991·American Journal of Respiratory Cell and Molecular Biology·D E Schellhase, J M Shannon
Feb 1, 1990·American Journal of Respiratory Cell and Molecular Biology·P L BallardM C Williams
Dec 1, 1990·The Journal of Clinical Investigation·J R WispéJ A Whitsett
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J W van der MeerC A Dinarello
May 1, 1988·Experimental Lung Research·B Robertson, B Lachmann
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S HawgoodR T White
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Mar 15, 1973·Experimental Cell Research·D L Shapiro, B K Schrier
Jul 15, 1981·Developmental Biology·J M SnyderJ M Johnston
Nov 1, 1995·American Journal of Respiratory and Critical Care Medicine·H J KrämerW Seeger
Feb 1, 1995·American Journal of Obstetrics and Gynecology·R MenonS J Fortunato
Feb 1, 1993·The Journal of Clinical Investigation·J M Klein, H C Nielsen
Mar 1, 1993·The American Review of Respiratory Disease·E D RiderA H Jobe
Feb 1, 1996·American Journal of Respiratory Cell and Molecular Biology·K RustE C Crouch
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

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Citations

Mar 12, 2008·Clinical Reviews in Allergy & Immunology·Rita M RyanSatyan Lakshminrusimha
Apr 8, 1999·Early Human Development·A H Jobe, M Ikegami
Apr 2, 2003·Seminars in Neonatology : SN·Alan H Jobe
May 23, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·M HallmanM Rämet
Sep 13, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Kazuhiro MoriMamoru Tanaka
Sep 1, 2007·Clinical Obstetrics and Gynecology·Francesca GotschSonia S Hassan
Jul 2, 2004·Journal of Paediatrics and Child Health·A Kent, J E Dahlstrom
Oct 22, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·M Murase, A Ishida
Jun 9, 2000·Annual Review of Physiology·A H Jobe, M Ikegami
Oct 12, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jennifer J P CollinsBoris W Kramer
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·A H JobeM Ikegami
Mar 19, 2002·American Journal of Respiratory and Critical Care Medicine·Timothy J M MossMachiko Ikegami
May 23, 2002·American Journal of Respiratory and Critical Care Medicine·Claude DananChristophe Delacourt
Mar 1, 2000·American Journal of Respiratory Cell and Molecular Biology·V GlumoffM Hallman
Aug 5, 2006·American Journal of Respiratory Cell and Molecular Biology·Kristina BryUrpo Lappalainen
May 5, 2009·American Journal of Respiratory Cell and Molecular Biology·Erica BäckströmKristina Bry
Dec 10, 1999·Pediatric Research·A J Jobe
Aug 24, 2001·Pediatric Research·M HallmanR A Ezekowitz
Mar 4, 2003·Pediatric Research·Ilene R S Sosenko, Alan H Jobe
Jan 24, 2004·Pediatric Research·Neil MulrooneyMachiko Ikegami
Mar 14, 2009·Molecular Endocrinology·Carole R Mendelson
Aug 3, 2000·Journal of Perinatal Medicine·T Lacaze-Masmonteil, F Audibert
Sep 29, 2004·Paediatric Drugs·Carl T D'Angio, William M Maniscalco
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jennifer C CondonCarole R Mendelson
Jun 18, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·B W Kramer
Oct 12, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·M GantertB W Kramer
Oct 2, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tinnakorn ChaiworapongsaJeffrey A Whitsett
Sep 1, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Joonho LeeBo Hyun Yoon
Mar 16, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tamara StampalijaTinnakorn Chaiworapongsa
Dec 18, 2014·Experimental Lung Research·Benjamin LopezVedang A Londhe
Mar 17, 2010·Pediatrics and Neonatology·Alan H Jobe
Oct 13, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Julio JimenezJan Deprest
Sep 8, 2012·Clinics in Perinatology·Alan H Jobe

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