Intraarterial biocompatibility of polyethylene terephthalate self-expandable stents implanted in porcine peripheral arteries

Academic Radiology
I de ScheerderH De Geest

Abstract

We tested deployment feasibility and intraarterial biocompatibility of polyethylene terephthalate (PET) self-expandable vascular stents in a porcine peripheral artery model. To assess the thrombogenicity and neointimal response to oversized PET self-expandable stents, we implanted 10 stents in porcine common iliac arteries, followed by a 6-mm balloon inflation to 6 atm. All pigs survived until the study termination 6 weeks after stent implantation. Control angiography revealed stent closure in three pigs. Minimal stent luminal diameter (MSLD) was measured using a semiautomated edge detection algorithm. The difference in MSLD after stent implantation and at control after 6 weeks was not significant (4.9 +/- 0.5 mm-->4.7 +/- 1.0 mm). Histopathologic examination showed signs of thrombotic occlusion and revascularization in occluded stents. In patient stents only a mild fibromuscular neointimal response was seen. PET self-expandable stents implanted in porcine iliac arteries are possibly thrombogenic but do not lead to a significant neointimal response.

References

Aug 1, 1992·Journal of the American College of Cardiology·S P KarasS B King
Nov 1, 1990·The American Journal of Cardiology·P J de FeyterP W Serruys
Sep 1, 1987·Radiology·H RousseauH Wallsten

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Citations

Oct 1, 1996·Catheterization and Cardiovascular Diagnosis·I K De ScheerderJ H Piessens
May 1, 1996·Cardiovascular and Interventional Radiology·K WilczekJ Piessens
Jun 9, 1998·Journal of Vascular and Interventional Radiology : JVIR·B L DolmatchR LaBounty
Jun 6, 2009·Journal of Vascular and Interventional Radiology : JVIR·Boris RadeleffGoetz M Richter
Nov 17, 2006·Journal of Interventional Cardiology·Suzan CommandeurWim J van der Giessen

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