Intraarterial calcium stimulation and intraoperative ultrasonography in the localization and resection of insulinomas

Surgery
C K BrownH Richard Alexander

Abstract

Standard imaging studies (computed tomography, magnetic resonance imaging, somatostatin receptor scintigraphy, ultrasonography, and angiography) correctly localize insulinomas in less than 50% of patients and provide no information about the feasibility of enucleation based on proximity of tumor to pancreatic duct. We reviewed our experience with intraarterial calcium stimulation (Ca-Stim) and intraoperative ultrasonography (IOUS) to localize and guide management of insulinomas. Thirty-six patients (14 men, 22 women, median age 44 years) with insulinomas were treated between August 1989 and June 1996. Preoperative imaging studies were obtained. Patients underwent abdominal exploration with IOUS. Fourteen were evaluated by a surgeon blinded to preoperative imaging results. Tumors (4 to 50 mm) were resected by enucleation (67%) or partial pancreatectomy (33%); all were cured. Sensitivities of computed tomography, magnetic resonance imaging, somatostatin receptor scintigraphy, ultrasonography, angiography, and Ca-Stim in localizing insulinomas were 24%, 45%, 17%, 13%, 43%, and 94%, respectively. Tumors were identified by blinded surgical exploration with IOUS in 12 of 14 patients (86%). All insulinomas were identified before opera...Continue Reading

References

Apr 1, 1992·Archives of Surgery·J L PasiekaR E Burney
Feb 28, 1981·Lancet·P R DaggettM J Raphael
Jun 1, 1996·The Australian and New Zealand Journal of Surgery·L A SussmanD E Whittle

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Citations

Feb 10, 2009·Der Radiologe·G NöldgeL Grenacher
Mar 22, 2007·Langenbeck's Archives of Surgery·Daniel CasanovaJulio Freijanes
Sep 12, 2000·Current Gastroenterology Reports·L Somogyi, G Mishra
Mar 15, 2005·Best Practice & Research. Clinical Endocrinology & Metabolism·James E Jackson
Mar 18, 2003·Diabetes Research and Clinical Practice·Takashi NagaiMasatomo Mori
Jun 26, 2002·Journal of the American College of Surgeons·Boaz HirshbergPhillip Gorden
Aug 11, 2000·Journal of Gastroenterology and Hepatology·S KidoH Watanabe
Aug 31, 2000·Surgery·F J BerendsH J Bonjer
Dec 14, 2001·Surgery·M IiharaT Obara
Dec 20, 2002·Surgery·Melanie L RichardsThomas J Giordano
Feb 6, 2007·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Tatsuo ShimuraHiroyuki Kuwano
Feb 7, 2008·The Journal of Clinical Endocrinology and Metabolism·Maya B LodishPhillip Gorden
Feb 5, 2009·The Journal of Clinical Endocrinology and Metabolism·Jean-Marc GuettierPhillip Gorden
Feb 12, 2010·Future Oncology·Joyce J ShinSteven K Libutti
Jul 1, 2008·Indian Journal of Psychiatry·Venkatesan Jagadheesan, Stelina Sophie Dina Suresh
May 8, 2014·World Journal of Gastroenterology : WJG·Abbas Al-KurdHaggi Mazeh
Sep 22, 2001·Clinical Imaging·A ChatziioannouL Vlachos
May 7, 2003·Asian Journal of Surgery·Masatoshi Iihara, Takao Obara
Jul 12, 2011·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Pei-Yin ChenShih-Ming Huang
Feb 3, 2016·International Journal of Endocrine Oncology·Tetsuhide Ito, Robert T Jensen
Jun 28, 2011·Critical Reviews in Oncology/hematology·Helle-Brit FiebrichElisabeth G E de Vries
Jan 4, 2007·ANZ Journal of Surgery·Jun C ChungYong I Kim
Mar 26, 2016·Surgical Oncology Clinics of North America·Eric P TammEric M Rohren
Nov 19, 2015·Journal of Endocrinological Investigation·J MoreraY Reznik
May 13, 2006·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Pankaj ShahF John Service
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·L Raymond ReynoldsDennis G Karounos
Apr 20, 2010·Expert Review of Endocrinology & Metabolism·Jean-Marc Guettier, Phillip Gorden
May 18, 2004·The Surgical Clinics of North America·Emily Finlayson, Orlo H Clark
Feb 22, 2005·American Journal of Surgery·Gerard V Aranha, Margo Shoup
Oct 20, 2009·The Surgical Clinics of North America·Aarti MathurSteven K Libutti
Aug 16, 2017·Endocrine-related Cancer·S M SadowskiF Triponez
Nov 29, 2007·Current Opinion in Oncology·Steven B GoldinMonika M Wahi
Dec 18, 2008·The Journal of Clinical Endocrinology and Metabolism·Philip E CryerUNKNOWN Endocrine Society
Sep 22, 2000·The Journal of Clinical Endocrinology and Metabolism·B HirshbergP Gorden
Nov 2, 2004·World Journal of Surgery·Ahmad Assalia, Michel Gagner
Sep 28, 2006·The Journal of Clinical Endocrinology and Metabolism·Partha KarAshley B Grossman
Aug 5, 2004·Wiener klinische Wochenschrift·Klaus KaczirekBruno Niederle
May 16, 2012·Arquivos brasileiros de endocrinologia e metabologia·João S FelícioBernardo Liberman
Jul 3, 2019·Frontiers in Endocrinology·Crystal D C Kamilaris, Constantine A Stratakis
Oct 24, 2006·Current Problems in Surgery·Elizabeth A MittendorfMichael J Demeure

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