Intraarterial Peptide Receptor Radionuclide Therapy Using 90Y-DOTATOC for Hepatic Metastases of Neuroendocrine Tumors.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Courtney Lawhn-HeathThomas A Hope

Abstract

Given the high frequency of liver metastases in neuroendocrine tumor patients, we aimed to determine whether hepatic intraarterial administration of 90Y-DOTATOC peptide receptor radionuclide therapy (PRRT) would increase treatment efficacy while reducing systemic toxicity compared with systemic toxicity from intravenous administration as previously reported in the literature. Methods: PRRT-naïve adult neuroendocrine tumor patients with liver-dominant metastases were enrolled in a prospective single-center, open-label pilot study. The patients underwent baseline PET/CT using intravenous 68Ga-DOTATOC. Then, 3.5 ± 0.2 GBq (94.7 ± 5.4 mCi) of 90Y-DOTATOC were administered into the proper hepatic artery over 30 min. The first 5 patients also received intraarterial 68Ga-DOTATOC and underwent PET/CT. All patients were followed for response (RECIST, version 1.1) (primary aim 2, safety) and toxicity (Common Terminology Criteria for Adverse Events, version 4.0) (primary aim 1, efficacy) for at least 6 mo, with optional follow-up for up to 1 y. In the subset of 5 patients who underwent both intravenous and intraarterial 68Ga-DOTATOC PET/CT, tumor SUVmax was compared between intravenous and intraarterial administration for hepatic tumors, ...Continue Reading

References

Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dik J KwekkeboomEric P Krenning
May 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dik J KwekkeboomEric P Krenning
Feb 28, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Flavio ForrerDik J Kwekkeboom
Dec 10, 2009·Endocrine-related Cancer·Dik J KwekkeboomEric P Krenning
Mar 31, 2010·Seminars in Nuclear Medicine·Stefan E PoolMarion de Jong
May 13, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Clemens KratochwilUwe Haberkorn
Jul 29, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Saima KhanDik J Kwekkeboom
Sep 6, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Lisa BodeiGiovanni Paganelli
Sep 24, 2011·Seminars in Radiation Oncology·Chandan Guha, Brian D Kavanagh
Oct 3, 2013·European Journal of Nuclear Medicine and Molecular Imaging·A RomerM A Walter
Oct 3, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Lisa BodeiIrvin M Modlin
Jan 12, 2017·The New England Journal of Medicine·Jonathan StrosbergUNKNOWN NETTER-1 Trial Investigators

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Citations

Mar 16, 2021·Current Oncology Reports·N S MinczelesT Brabander

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