Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6

Case Reports in Neurology
Nnadozie Ezerioha, Wuwei Feng

Abstract

Cerebral aneurysms are well known to be associated with cardiac myxomas. The mechanism of cerebral aneurysm formation remains to be elucidated. Embolization of tumor particles in the vessel wall has been proposed as the likely mechanism for aneurysm formation. Recent reports suggest interleukin-6 (IL-6) may play a role as well. We describe a patient who presented with subarachnoid hemorrhage secondary to ruptured right middle cerebral artery (MCA) aneurysm and unruptured left MCA aneurysm. Subsequently, the patient was found to have an atrial myxoma and persistently elevated serum IL-6 levels. Transcranial Doppler monitoring showed multiple emboli in the right MCA vascular territory on day 1 after surgery but no recurrent embolization during the next 2 weeks on repeated tests. Elevated IL-6 levels were noted both on day 1 and on day 30. Our findings provide evidence that IL-6 elevation and not tumor embolization is likely the culprit for aneurysm formation in some patients with atrial myxoma.

Citations

Aug 11, 2020·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Cristian AguilarJoham Choque-Velasquez
Nov 6, 2018·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Alejandro SantillanY Pierre Gobin
Sep 16, 2019·World Neurosurgery·Shiying GaiQinghai Huang
Oct 16, 2021·Shock·Allan E StolarskiDaniel G Remick
Jan 29, 2021·Case Reports in Neurology·Swati JainNarayanaswamy Venketasubramanian

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