PMID: 9554729Apr 29, 1998Paper

Intracardiac stimulation of human parasympathetic nerve fibers induces negative dromotropic effects: implication with the lesions of radiofrequency catheter ablation

Journal of Cardiovascular Electrophysiology
S A ChenM S Chang

Abstract

The dromotropic effects of intracardiac parasympathetic nerve stimulation have not been well studied; furthermore, the effects of radiofrequency ablation lesions on parasympathetic nerve stimulation are not clear. Group I: intracardiac electrical stimulation in the right posteroseptal and anteroseptal areas under different stimulation strengths; group II: intracardiac electrical stimulation before and 10 minutes after intravenous propranolol; group III: intracardiac electrical stimulation before and 5 minutes after intravenous atropine. Among the 10 patients with AV nodal reentrant tachycardia (group IV) and the 10 patients with atrial flutter (group V), atrial fibrillation was induced before and after successful ablation, and intracardiac electrical stimulation in the right posteroseptal area was performed before and after successful ablation. The maximal response and complete decay of the response occurred within 2 to 6 seconds of initiation or termination of parasympathetic nerve stimulation. This negative dromotropic effect disappeared after atropine was administered, but not after propranolol. After successful ablation, parasympathetic stimulation still induced negative dromotropic effects. Electrical stimulation of parasy...Continue Reading

References

Jan 1, 1973·The American Journal of Physiology·W P GeisW C Randall
Feb 1, 1973·Circulation·J E Edwards, D C McGoon
Dec 31, 1998·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·I GiorgberidzeP Mathew
Dec 31, 1998·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·R J VerdinoJ T Barbey

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Citations

Oct 13, 2006·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Alberto DiazKara J Quan
Dec 10, 1999·Journal of the American College of Cardiology·P SchauerteR Lazzara
Oct 12, 1999·Journal of Cardiovascular Electrophysiology·C C WuL Tung
Mar 1, 2000·Journal of Cardiovascular Electrophysiology·P SchauerteR Lazzara
Oct 5, 2011·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Lilian KornetRichard Cornelussen
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Paresh ShahDan Dan
Dec 12, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Jian CuiLawrence I Sinoway
Nov 17, 2009·Journal of Cardiovascular Electrophysiology·Jacques Billette, Rafik Tadros
Dec 23, 2004·Pacing and Clinical Electrophysiology : PACE·Steven M MarkowitzBruce B Lerman

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