Intracarotid delivery of drugs: the potential and the pitfalls.

Anesthesiology
Shailendra JoshiEugene Ornstein

Abstract

The major efforts to selectively deliver drugs to the brain in the past decade have relied on smart molecular techniques to penetrate the blood-brain barrier, whereas intraarterial drug delivery has drawn relatively little attention. Meanwhile, rapid progress has been made in the field of endovascular surgery. Modern endovascular procedures can permit highly targeted drug delivery by the intracarotid route. Intracarotid drug delivery can be the primary route of drug delivery or it could be used to facilitate the delivery of smart neuropharmaceuticals. There have been few attempts to systematically understand the kinetics of intracarotid drugs. Anecdotal data suggest that intracarotid drug delivery is effective in the treatment of cerebral vasospasm, thromboembolic strokes, and neoplasms. Neuroanesthesiologists are frequently involved in the care of such high-risk patients. Therefore, it is necessary to understand the applications of intracarotid drug delivery and the unusual kinetics of intracarotid drugs.

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Citations

Apr 11, 2009·International Anesthesiology Clinics·Carsten Nadjat-HaiemIrene Osborn
Jul 25, 2012·Anesthesia Progress·Soudeh CheginiDaljit K Dhariwal
Dec 6, 2014·Journal of Neuroanaesthesiology and Critical Care·Shailendra JoshiCharles W Emala
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Jan 29, 2016·Journal of Drug Delivery·Jason A EllisShailendra Joshi
Jul 17, 2010·Annals of the New York Academy of Sciences·Shailendra Joshi, Sachin Agarwal
Feb 26, 2016·Nanomedicine·Radka GromnicovaDavid Male
Apr 20, 2016·Drug Delivery and Translational Research·Shailendra JoshiRobert M Straubinger
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Dec 5, 2021·AAPS PharmSciTech·Nkafu Bechem NdemazieEdward Agyare

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