Intracavernosal administration of sodium nitrite as an erectile pharmacotherapy

Canadian Journal of Physiology and Pharmacology
George F LaskerP J Kadowitz

Abstract

It has been reported that sodium nitrite (NaNO2) can act as a storage form of nitric oxide (NO) that can have beneficial pharmacologic actions. The present study was undertaken to investigate the effects of NaNO2 on erectile function in the rat. The intracavernosal (i.c.) injection of NaNO2 produced dose-related increases in i.c. pressure and decreases in systemic arterial pressure. NaNO2 was 1000-fold less potent than sodium nitroprusside in increasing i.c. pressure. Increases in i.c. pressure in response to NaNO2 were attenuated by the nitric oxide synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME). The increases in i.c. pressure in response to NaNO2 were not altered by the xanthine oxidoreductase inhibitor allopurinol. The decreases in systemic arterial pressure in response to i.c. injections of NaNO2 were attenuated by allopurinol and were either unchanged or increased by L-NAME. These data suggest that NaNO2 is converted to vasoactive NO in the corpora cavernosum and systemic vascular bed of the rat by different mechanisms. The present data suggest that the conversion of NaNO2 to vasoactive NO is mediated by NOS in the corpora cavernosum and by xanthine oxidoreductase in the systemic vascular bed of the rat....Continue Reading

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Citations

Dec 15, 2010·Advances in Pharmacological Sciences·George F LaskerPhilip J Kadowitz
Jan 21, 2012·BJU International·Serap GurWayne J G Hellstrom
Apr 15, 2016·International Journal of Impotence Research·A I El-Sakka
Mar 26, 2014·British Journal of Pharmacology·G Yetik-AnacakN Murat
Jun 6, 2014·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Ozge UnSerap Gur

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