PMID: 11918246Mar 29, 2002Paper

Intracavernosal alprostadil is effective for the treatment of erectile dysfunction in diabetic men

International Journal of Impotence Research
J P HeatonA Belanger

Abstract

The efficacy and safety of intracavernosal alprostadil was evaluated for the treatment of erectile dysfunction in men with type I or type II diabetes mellitus. This was an open-label, flexible dose-escalating study involving 336 men (77% of whom were Asian/Oriental) enrolled by 15 centres in Australia, Canada and seven countries in Asia. The effective alprostadil dose, ie the dose producing penile rigidity adequate for intercourse and lasting up to 60 min, was established by titration at the clinic prior to entry into the 6 month self-treatment home phase. All men were fully trained in the self-injection technique before entry into the home phase. Efficacy and safety were assessed using patient and partner diaries and by interview at clinic visits during the titration phase and after 1, 3 and 6 months of treatment. An effective home dose was established by titration for 94% of the 336 men (median dose 20 microg, range 2.5-60 microg). Of 278 (83%) men who entered the home phase, 277 men (247 with type II diabetes and 30 with type I diabetes) had evaluable data for alprostadil dosage and clinical response. During the home phase, a satisfactory erectile response was achieved after 99% of injections, and the median alprostadil dose...Continue Reading

References

Apr 1, 1980·Diabetologia·D K McCullochB F Clarke
Jan 1, 1993·Urologia Internationalis·C J WangC P Chiang
Jan 1, 1996·Diabetic Medicine : a Journal of the British Diabetic Association·J Bancroft, P Gutierrez
Aug 1, 1996·Diabetic Medicine : a Journal of the British Diabetic Association·W D Dunsmuir, S A Holmes
Jun 5, 1999·International Journal of Impotence Research·M J Metro, G A Broderick
Sep 24, 1999·The Journal of Urology·J P MulhallI Goldstein

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Citations

Sep 13, 2008·International Journal of Impotence Research·A D Seftel
Apr 21, 2006·International Journal of Impotence Research·D GolijaninV Dogra
Feb 24, 2006·Asian Journal of Andrology·P PerimenisA Athanasopoulos
Aug 8, 2006·Asian Journal of Andrology·Charles R Moore, Run Wang
May 27, 2009·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·V PhéS Beley
Sep 7, 2014·Current Diabetes Reports·Konstantinos Hatzimouratidis, Dimitrios Hatzichristou
Mar 6, 2015·Expert Opinion on Emerging Drugs·Taylor C PeakWayne J G Hellstrom
May 18, 2016·Nature Reviews. Disease Primers·Faysal A YafiWayne J G Hellstrom
Jan 19, 2008·Expert Opinion on Pharmacotherapy·Yun ChenRun Wang
May 14, 2008·Expert Opinion on Pharmacotherapy·Raymond A CostabileKathleen Hwang
Apr 2, 2003·Expert Opinion on Therapeutic Targets·Liming JinR Clinton Webb
May 20, 2015·Der Urologe. Ausg. A·M TrottmannC G Stief
Sep 18, 2013·The World Journal of Men's Health·Ji Kan RyuSoo Woong Kim
Oct 22, 2004·International Journal of Impotence Research·J M Miralles-García, L C García-Díez
Mar 24, 2020·The World Journal of Men's Health·Soyeun KimMahadevan Raj Rajasekaran
Aug 17, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nelisiwe Prenate MasukuSogolo Lucky Lebelo
Sep 14, 2021·Diabetes/metabolism Research and Reviews·Giuseppe DefeudisDaniele Gianfrilli

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