Intracellular adhesion molecule concentrations in women who smoke during pregnancy

Obstetrics and Gynecology
Kristine Y LainJ A DeLoia

Abstract

Smoking and endothelial dysfunction are associated with adverse pregnancy outcomes. The effect of smoking on vascular endothelium during pregnancy has not been well studied. Our objectives were to determine if smoking has an impact on endothelial function in pregnancy by comparing markers of endothelial function and to evaluate the contribution from different cellular sources. We measured markers of endothelial function in a prospective cohort of 198 primiparous women who had 325 plasma samples obtained throughout pregnancy. Samples were assayed for intracellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin. Smoking status was determined by serum cotinine concentration. Analyses of adhesion molecules were performed for 4 gestational age intervals by using Mann-Whitney and Kruskal-Wallis tests. Gene expression for ICAM-1 was determined by real-time polymerase chain reaction from placental biopsies. A human umbilical vein endothelial cell (HUVEC) culture model was utilized to evaluate the effect of cotinine on endothelial cell production of ICAM-1. ICAM-1 is increased, VCAM-1 was not different, and E-selectin was decreased among smokers at various times during pregnancy. Placental produ...Continue Reading

References

Jan 1, 1995·American Journal of Reproductive Immunology : AJRI·C A Labarrere, W P Faulk
Feb 15, 1997·The American Journal of Cardiology·J LekakisS Moulopoulos
Feb 13, 1999·American Journal of Obstetrics and Gynecology·C W RedmanI L Sargent
Oct 16, 1999·American Journal of Obstetrics and Gynecology·A Conde-AgudeloA C Kafury-Goeta
Mar 1, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·N TakeuchiN Hotta
Apr 23, 2002·Acta Obstetricia Et Gynecologica Scandinavica·Rune LindqvistAnders Håkansson
Jan 29, 2003·Circulation·Sashi GuthikondaWilliam G Haynes
Apr 2, 2003·Toxicology and Applied Pharmacology·Usamah S KayyaliPaul M Hassoun
Oct 31, 2003·American Journal of Obstetrics and Gynecology·Kristine Y LainJames M Roberts
Mar 5, 2004·The American Journal of Cardiology·Sashi GuthikondaWilliam G Haynes
Jan 12, 2005·Journal of Hypertension·John DeanfieldUNKNOWN Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension
Jul 28, 2005·The Journal of Clinical Endocrinology and Metabolism·Kristine Y LainJames M Roberts

❮ Previous
Next ❯

Citations

Dec 1, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Frank LüdickeRolf Weitkunat
Dec 13, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Patrizia LuppiJulie A DeLoia
Sep 30, 2008·Arquivos brasileiros de endocrinologia e metabologia·Eliana M Da Ros WendlandMaria Inês Schmidt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.