PMID: 11322719Apr 27, 2001Paper

Intracellular and extracellular regulation of ureteric bud morphogenesis

Journal of Anatomy
Jamie A Davies

Abstract

The urinary collecting duct system of the permanent kidney develops by growth and branching of an initially unbranched epithelial tubule, the ureteric bud. Formation of the ureteric bud as an outgrowth of the wolffian duct is induced by signalling molecules (such as GDNF) that emanate from the adjacent metanephrogenic mesenchyme. Once it has invaded the mesenchyme, growth and branching of the bud is controlled by a variety of molecules, such as the growth factors GDNF, HGF, TGFbeta, activin, BMP-2, BMP-7, and matrix molecules such as heparan sulphate proteoglycans and laminins. These various influences are integrated by signal transduction systems inside ureteric bud cells, with the MAP kinase, protein kinase A and protein kinase C pathways appearing to play major roles. The mechanisms of morphogenetic change that produce branching remain largely obscure, but matrix metalloproteinases are known to be necessary for the process, and there is preliminary evidence for the involvement of the actin/myosin contractile cytoskeleton in creating branch points.

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Citations

May 6, 2003·Developmental Biology·Aurora F Esquela, Se-Jin Lee
Nov 25, 2003·Kidney International·Sanjay K Nigam
Dec 26, 2001·Current Opinion in Nephrology and Hypertension·Youhua Liu
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Jun 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jessica TomaszewskiHumphrey Hung-Chang Yao
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Mar 28, 2009·Journal of Theoretical Biology·Tsuyoshi HirashimaYoshihiro Morishita
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Jan 5, 2012·Hypertension·Tilmann DittingRoland Veelken

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