Intracellular and Plasma Membrane Events in Cholesterol Transport and Homeostasis

Journal of Lipids
Dmitry Y LitvinovAlexander D Dergunov

Abstract

Cholesterol transport between intracellular compartments proceeds by both energy- and non-energy-dependent processes. Energy-dependent vesicular traffic partly contributes to cholesterol flux between endoplasmic reticulum, plasma membrane, and endocytic vesicles. Membrane contact sites and lipid transfer proteins are involved in nonvesicular lipid traffic. Only "active" cholesterol molecules outside of cholesterol-rich regions and partially exposed in water phase are able to fast transfer. The dissociation of partially exposed cholesterol molecules in water determines the rate of passive aqueous diffusion of cholesterol out of plasma membrane. ATP hydrolysis with concomitant conformational transition is required to cholesterol efflux by ABCA1 and ABCG1 transporters. Besides, scavenger receptor SR-B1 is involved also in cholesterol efflux by facilitated diffusion via hydrophobic tunnel within the molecule. Direct interaction of ABCA1 with apolipoprotein A-I (apoA-I) or apoA-I binding to high capacity binding sites in plasma membrane is important in cholesterol escape to free apoA-I. ABCG1-mediated efflux to fully lipidated apoA-I within high density lipoprotein particle proceeds more likely through the increase of "active" chole...Continue Reading

References

Jan 1, 1989·Annual Review of Cell Biology·G van Meer
Aug 1, 1985·The Journal of Cell Biology·M R Kaplan, R D Simoni
Aug 4, 1980·Biochimica Et Biophysica Acta·M H Gottlieb
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·M MurataK Simons
Nov 7, 1995·Biochemistry·P E Fielding, C J Fielding
Nov 15, 1996·The Journal of Biological Chemistry·E J SmartR G Anderson
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·M L VarbanD Huszar
Feb 25, 1999·Biochemistry·C J FieldingP E Fielding
Mar 27, 1999·The Journal of Biological Chemistry·B StahlT C Südhof
Apr 27, 1999·Biochimica Et Biophysica Acta·L Liscum, N J Munn
Apr 12, 2000·Biochemistry·M P HaynesG H Rothblat
Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·M IkemotoK Inoue
Jul 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·S HeinoE Ikonen
Jul 20, 2000·Archives of Biochemistry and Biophysics·J D ToledoH A Garda
Aug 24, 2000·The Journal of Biological Chemistry·B P AtshavesF Schroeder
May 12, 2001·The Journal of Biological Chemistry·E B NeufeldH B Brewer
Nov 6, 2001·Progress in Lipid Research·Henna Ohvo-RekiläJ Peter Slotte
Jan 25, 2002·Annals of the New York Academy of Sciences·A BoullierJ L Witztum
Feb 8, 2003·Annual Review of Biophysics and Biomolecular Structure·Harden M McConnell, Marija Vrljic
Jan 7, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Guilhem LarigauderieMustapha Rouis
Jan 20, 2004·The Journal of Biological Chemistry·Ying FuDmitri Sviridov
May 8, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Raymond E Soccio, Jan L Breslow
Jun 9, 2004·Biochemistry·Minglong ZhouFriedhelm Schroeder
Aug 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yvonne LangeTheodore L Steck

❮ Previous
Next ❯

Citations

Jun 18, 2019·Journal of Cellular Physiology·Jijia HuGuohua Ding
Oct 3, 2019·Current Opinion in Lipidology·Fabrizia BonacinaGiuseppe D Norata
Feb 1, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Jorge MontesinosEstela Area-Gomez
Sep 16, 2020·Traffic·Yvonne Lange, Theodore L Steck
Jun 14, 2019·Frontiers in Immunology·Philipp M HagemannZane Orinska
Nov 12, 2019·Frontiers in Molecular Biosciences·Mariafrancesca ScaliseCesare Indiveri
Nov 5, 2019·Frontiers in Cell and Developmental Biology·Charlene BörtleinElita Avota
Aug 8, 2020·Journal of Biochemical and Molecular Toxicology·Nimai C Chandra
Oct 9, 2019·Annual Review of Cell and Developmental Biology·Tamas BallaJoshua Pemberton
Aug 6, 2020·Biomedicines·Vasily N SukhorukovAlexander N Orekhov
May 30, 2020·Cellular and Molecular Neurobiology·Shwetha NanjundaiahSubashchandrabose Chinnathambi
Oct 9, 2020·Pharmaceuticals·Barbara Guerra, Olaf-Georg Issinger
Nov 12, 2020·International Journal of Molecular Sciences·Kang-Hoon LeeJe-Yoel Cho
Dec 10, 2020·The Journal of Biological Chemistry·Mitsuhiro NakatoKazumitsu Ueda
Jan 23, 2021·The Journal of Biological Chemistry·Mitsuhiro NakatoKazumitsu Ueda
Feb 22, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lewis J MartinMichael T Bowen
Sep 1, 2020·Neurobiology of Disease·Rishi R AgrawalMarta Pera
Sep 30, 2020·Colloids and Surfaces. B, Biointerfaces·Elsa M MateronOsvaldo N Oliveira
Apr 10, 2021·Atherosclerosis·Daan M van VelzenMassimiliano Ruscica
Jun 15, 2021·Frontiers in Cell and Developmental Biology·Divya Saro Varghese, Bassam R Ali
Jul 15, 2021·Nature Reviews. Drug Discovery·Jian Payandeh, Matthew Volgraf
Jul 19, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Richard J LightbodyAnnette Graham
Aug 26, 2021·Computational and Structural Biotechnology Journal·Michal MarkiewiczMarta Pasenkiewicz-Gierula
Jan 5, 2022·Journal of Cell Science·Adi ZhengChristian Widmann

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
gene knockout
GTPases
ubiquitination

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.