Intracellular Ca2+ Release and Synaptic Plasticity: A Tale of Many Stores

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
Zahid PadamseyNigel J Emptage

Abstract

Ca2+ is an essential trigger for most forms of synaptic plasticity. Ca2+ signaling occurs not only by Ca2+ entry via plasma membrane channels but also via Ca2+ signals generated by intracellular organelles. These organelles, by dynamically regulating the spatial and temporal extent of Ca2+ elevations within neurons, play a pivotal role in determining the downstream consequences of neural signaling on synaptic function. Here, we review the role of three major intracellular stores: the endoplasmic reticulum, mitochondria, and acidic Ca2+ stores, such as lysosomes, in neuronal Ca2+ signaling and plasticity. We provide a comprehensive account of how Ca2+ release from these stores regulates short- and long-term plasticity at the pre- and postsynaptic terminals of central synapses.

References

May 25, 1992·Neuroscience Letters·J Harvey, G L Collingridge
Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·T V BlissJ H Williams
Jun 1, 1984·Arthritis and Rheumatism·I BercziK Kovacs
Mar 28, 1998·Trends in Biochemical Sciences·J Meldolesi, T Pozzan
Sep 30, 1998·The European Journal of Neuroscience·E Korkotian, M Segal
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M NaritaY Tsujimoto
Aug 14, 1999·European Journal of Biochemistry·B E LinebaughD Keppler
Oct 26, 1999·Trends in Neurosciences·O H Petersen, J M Cancela
Feb 7, 2001·Mutation Research·M AbbaF N Dulout
Aug 16, 2001·Trends in Biochemical Sciences·S PatelA Galione
Feb 8, 2002·Neuron·Bernardo L SabatiniKarel Svoboda
Mar 22, 2002·The Journal of Biological Chemistry·Edwin J WeeberWilliam J Craigen
Apr 4, 2002·Journal of Neurophysiology·Suya Zhou, William N Ross
Apr 12, 2002·Journal of Perinatology : Official Journal of the California Perinatal Association·Anita Catlin, Brian Carter
Jun 11, 2002·Nature Neuroscience·Thomas G OertnerKarel Svoboda
Jul 2, 2002·Journal of Neurophysiology·Clarke R Raymond, Stephen J Redman
Feb 27, 2003·The Journal of Biological Chemistry·Michael LevyJ David Sweatt

❮ Previous
Next ❯

Citations

Jul 14, 2019·Hippocampus·Rahul K Rathour, Rishikesh Narayanan
Oct 12, 2019·Science·Pedro Guedes-Dias, Erika L F Holzbaur
Nov 24, 2020·Acta Neuropathologica·Tam T QuachAnne-Marie Duchemin
Jul 16, 2021·Scientific Reports·Sudhanva S KashyapRichard J Martin

❮ Previous
Next ❯

Methods Mentioned

BETA
antisense oligonucleotides

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.