Intracellular Ca2+ store depletion induces the formation of macromolecular complexes involving hTRPC1, hTRPC6, the type II IP3 receptor and SERCA3 in human platelets

Biochimica Et Biophysica Acta
Pedro C RedondoJuan A Rosado

Abstract

Endogenously expressed human canonical transient receptor potential 1 (hTRPC1) and human canonical transient receptor potential 6 (hTRPC6) have been shown to play a role in store-operated Ca2+ entry (SOCE) in human platelets, where two mechanisms for SOCE, regulated by the dense tubular system (DTS) or the acidic granules, have been identified. In cells preincubated for 1 min with 100 microM flufenamic acid we show that hTRPC6 is involved in SOCE activated by both mechanisms, as demonstrated by selective depletion of the DTS or the acidic stores, using thapsigargin (TG) (10 nM) or 2,5-di-(tert-butyl)-1,4-hydroquinone (TBHQ) (20 microM), respectively, although it is more relevant after acidic store depletion. Co-immunoprecipitation experiments indicated that depletion of both stores separately results in time-dependent interaction between hTRPC1 and hTRPC6, and also between both hTRPCs and the type II IP3 receptor (IP3RII). The latter was greater after treatment with TG. TBHQ-induced coupling between hTRPC1 and 6 was transient and decreased after 30s of treatment, while that induced by TG increased for at least 3 min. TBHQ induced association between SERCA3, located in the acidic stores, hTRPC1, hTRPC6 and Orai1. TBHQ also evoke...Continue Reading

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Citations

Jun 3, 2009·Nature Cell Biology·Michael D Cahalan
Jun 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gayatri Venkiteswaran, Gaiti Hasan
Sep 24, 2010·Cold Spring Harbor Perspectives in Biology·Maarten GeesBernd Nilius
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Oct 1, 2013·Blood Cells, Molecules & Diseases·Alejandro Berna-ErroJuan A Rosado
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Apr 29, 2008·Biochemical Pharmacology·Jose J LópezJuan A Rosado
Jul 28, 2009·Journal of Thrombosis and Haemostasis : JTH·W Bergmeier, L Stefanini
Apr 13, 2013·Journal of Cellular and Molecular Medicine·Esther LópezPedro Cosme Redondo
Dec 6, 2011·Journal of Thrombosis and Haemostasis : JTH·A Smolenski
Apr 30, 2015·Cell Calcium·Hwei Ling Ong, Indu S Ambudkar
Jun 18, 2015·Journal of Physiology and Biochemistry·Esther LopezPedro C Redondo
Aug 5, 2014·The Biochemical Journal·Letizia AlbarránJuan A Rosado
Dec 12, 2012·Biochimica Et Biophysica Acta·Esther LópezPedro C Redondo
Jul 30, 2011·Biochemical and Biophysical Research Communications·Alfonsas Juška
Dec 31, 2011·Biochemical and Biophysical Research Communications·Enma V Paez EspinosaFadi T Khasawneh
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Apr 5, 2013·IUBMB Life·Isaac JardinJuan A Rosado
Mar 20, 2010·Expert Opinion on Therapeutic Targets·Xia DingYizheng Wang
Mar 23, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Neerupma SilswalJon Andresen
Aug 22, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Isaac JardinJuan A Rosado
Aug 15, 2009·Chemical Reviews·Peter VangheluweJo Vanoevelen
Jun 29, 2021·Frontiers in Oncology·María Paz SaldíasOscar Cerda
Aug 22, 2009·Archives of Biochemistry and Biophysics·C GalánJ A Rosado
Nov 9, 2010·Thrombosis Research·Peter F Blackmore

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