PMID: 8607469Mar 1, 1996Paper

Intracellular calcium response to hydraulic pressure in human periodontal ligament fibroblasts

American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
C Nakago-MatsuoT Nakago

Abstract

Human periodontal ligament fibroblasts in culture were exposed to the controlled change in hydraulic pressure and were monitored continuously with an electric pressure gauge, and the concentration of intracellular calcium was measured in real time by a calcium-binding fluorescent dye, fluo-3. The elevation of hydraulic pressure to a level ranging from 20 to 50 mm Hg induced transient elevation of the intracellular calcium concentration in about 10% of the fibroblasts observed, indicating that these cells could respond to the pressure change. The results supported further an idea that periodontal ligament fibroblasts, responding to the pressure exerted by orthodontic force, would initiate the chain of events in orthodontic tooth movement, including alveolar bone remodeling. The threshold level of pressure (27 to 68 g/cm2) obtained in this experiment, at which the fibroblasts started to respond, would provide a biochemical basis to determine the optimal magnitude of stress for clinical orthodontics.

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Citations

Apr 27, 1999·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·A G Macdonald, P J Fraser
Jun 1, 1996·The British Journal of Ophthalmology·T Matsuo, N Matsuo
Jan 26, 2011·The Journal of Prosthetic Dentistry·Mansuang ArksornnukitHidekazu Takahashi
Oct 27, 2009·The Journal of Prosthetic Dentistry·Thitima PhunthikaphadrMansuang Arksornnukit
Jul 13, 2012·Archives of Oral Biology·Hardus StrydomJohannes W Von den Hoff
Sep 21, 2007·American Journal of Physiology. Renal Physiology·Nalini V BroadbeltDiane Felsen
Jun 27, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ei Ei Hsu HlaingHiroshi Kamioka
Jan 8, 1999·Journal of Periodontal Research·P S HowardJ M Korostoff
Oct 16, 2019·Microscopy·Kouji InoueTetsuji Sato

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