PMID: 6538879Apr 1, 1984Paper

Intracellular control of axial shape in non-uniform neurites: a serial electron microscopic analysis of organelles and microtubules in AI and AII retinal amacrine neurites

The Journal of Cell Biology
S E Sasaki-SherringtonJ K Stevens

Abstract

AI and AII cat retinal amacrine cells have highly varicose non-uniform, neuritic processes. Processes of both types were reconstructed via a computer system using serial electron micrographs. These reconstructions were analyzed for (a) varicosity volume, surface area, and length, (b) "neck" volume, surface area, and length, (c) number of microtubules within the varicosity, (d) number of microtubules within the "neck," and (e) volume and surface area of mitochondria and smooth endoplasmic reticulum and large smooth vesicular bodies within the processes. Correlation of these parameters revealed a linear relationship between the number of microtubules in the necks and mean neck cross-sectional area (rs = 0.780, P less than 0.001), while microtubule number within the varicosities showed no correlation with varicosity volume (rs = 0.239, P greater than 0.2). Varicosity volume did, however, correlate strongly with the summed volume of mitochondria and smooth vesicular bodies contained within the varicosity for both cell types examined. The ratio between membranous organelle volume and varicosity volume for AI amacrine processes of 1:6.97 (rs = 0.927), differed from the ratio of 1:1.80 for the AII amacrine processes (rs = 0.987). Simi...Continue Reading

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Citations

Dec 1, 1990·Journal of Neurocytology·M M GreenbergJ K Stevens
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M M Black
Jan 1, 1991·Annals of the New York Academy of Sciences·G A Lnenicka
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gordon M G ShepherdPer Andersen
Sep 16, 1988·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H J Wagner, E Wagner

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