Intracellular copper accumulation enhances the growth of Kineococcus radiotolerans during chronic irradiation

Applied and Environmental Microbiology
Christopher E BagwellD A Blom

Abstract

The actinobacterium Kineococcus radiotolerans is highly resistant to ionizing radiation, desiccation, and oxidative stress, though the underlying biochemical mechanisms are unknown. The purpose of this study was to explore a possible linkage between the uptake of transition metals and extreme resistance to ionizing radiation and oxidative stress. The effects of six different divalent cationic metals on growth were examined in the absence of ionizing radiation. None of the metals tested were stimulatory, though cobalt was inhibitory to growth. In contrast, copper supplementation dramatically increased colony formation during chronic irradiation. K. radiotolerans exhibited specific uptake and intracellular accumulation of copper, compared to only a weak response to both iron and manganese supplementation. Copper accumulation sensitized cells to hydrogen peroxide. Acute-irradiation-induced DNA damage levels were similar in the copper-loaded culture and the age-synchronized no-copper control culture, though low-molecular-weight DNA was more persistent during postirradiation recovery in the Cu-loaded culture. Still, the estimated times for genome restoration differed by only 2 h between treatments. While we cannot discount the possi...Continue Reading

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Sep 25, 2010·PloS One·Christopher E BagwellKarl K Weitz
May 15, 2013·Journal of Environmental Radioactivity·Carmel Mothersill, Colin Seymour
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Jul 1, 2017·The Journal of Microbiology·Kwang-Woo JungYong-Sun Bahn

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