Intracellular delivery of a membrane-impermeable enzyme in active form using functionalized gold nanoparticles.

Journal of the American Chemical Society
Partha GhoshVincent M Rotello

Abstract

Gold nanoparticles were coated with a short peptide to promote intracellular delivery of membrane-impermeable proteins. Through microscopy and enzyme assays, we demonstrated the particles were able to transport functional enzymes into a variety of cell lines. Significantly, the transported proteins were able to escape from endosomes. Moreover, these particles showed no apparent cytotoxicity.

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