Intracellular detection of viral nucleic acids

Current Opinion in Microbiology
Konstantin M J Sparrer, Michaela U Gack

Abstract

Successful clearance of a microbial infection depends on the concerted action of both the innate and adaptive arms of the immune system. Accurate recognition of an invading pathogen is the first and most crucial step in eliciting effective antimicrobial defense mechanisms. In recent years, remarkable progress has been made towards understanding the molecular details of how the innate immune system recognizes microbial signatures, commonly called pathogen-associated molecular patterns (PAMPs). For viral pathogens, nucleic acids-both viral genomes and viral replication products-represent a major class of PAMPs that trigger antiviral host responses via activation of germline-encoded innate immune receptors. Here we summarize recent advances in intracellular innate sensing mechanisms of viral RNA and DNA.

References

Oct 14, 2006·Science·Andreas PichlmairCaetano Reis e Sousa
Oct 14, 2006·Science·Veit HornungGunther Hartmann
Dec 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Takeshi SaitoMichael Gale
Aug 7, 2009·Journal of Virology·Andreas PichlmairCaetano Reis e Sousa
Aug 25, 2009·Nature Immunology·Ahmed SabbahSantanu Bose
Feb 11, 2010·Cell·Jan RehwinkelCaetano Reis e Sousa
Mar 23, 2010·Cell·Osamu Takeuchi, Shizuo Akira
Mar 31, 2010·Nature Immunology·Vijay A K RathinamKatherine A Fitzgerald
Sep 2, 2010·Proceedings of the National Academy of Sciences of the United States of America·Alina BaumAdolfo García-Sastre
Oct 5, 2010·Nature Immunology·Leonie UnterholznerAndrew G Bowie
Jul 28, 2011·Molecular and Cellular Biology·Moeko MiyashitaTsukasa Seya
Nov 13, 2012·Cell Reports·Qian FengFrank J M van Kuppeveld
Jan 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jesse DonovanAlexei Korennykh
May 28, 2013·Immunity·Delphine GoubauCaetano Reis e Sousa
Aug 21, 2013·Immunological Reviews·Christopher Lupfer, Thirumala-Devi Kanneganti
Oct 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Martin R JakobsenSøren R Paludan
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Seamus R MorroneJungsan Sohn
Feb 20, 2014·ELife·Safia DeddoucheCaetano Reis e Sousa
Feb 22, 2014·Annual Review of Immunology·William M SchneiderCharles M Rice
Feb 27, 2014·MBio·Shuvojit BanerjeeRobert H Silverman
Apr 20, 2014·PLoS Pathogens·Simon RungeKarl-Peter Hopfner
Jul 9, 2014·Annual Review of Microbiology·Megan H Orzalli, David M Knipe

❮ Previous
Next ❯

Citations

Mar 30, 2016·Cytokine & Growth Factor Reviews·Carmela Lussi, Matthias Schweizer
Sep 19, 2015·Nature Immunology·Jessica J Chiang, Michaela U Gack
Jun 12, 2016·Current Opinion in Microbiology·Dia C Beachboard, Stacy M Horner
Jun 25, 2016·Viruses·Jennifer Deborah Wuerth, Friedemann Weber
May 21, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kamila S GwiazdaAndrew M Scharenberg
Jul 6, 2016·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Giulia MarsiliAngela Battistini
Jun 3, 2016·ELife·Yen-Li LiWesley I Sundquist
Oct 30, 2016·Current Opinion in Virology·Michaela U Gack, Michael S Diamond
Apr 5, 2017·IUBMB Life·Nanhua ChenJianzhong Zhu
Feb 15, 2017·Nature Communications·Jessica F AlmineLeonie Unterholzner
Jun 20, 2017·Journal of Molecular Biology·Ben A Bailey-ElkinBrian L Mark
Jul 21, 2017·Journal of Virology·Eun Jin JeonKenji S Nakahara
Feb 19, 2016·Journal of Virology·Jun ZhaoPinghui Feng
Feb 13, 2016·Journal of Virology·Bjoern Meyer, Hinh Ly
Nov 4, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vincent T Marchesi
Feb 23, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zeming ZhangFuping You
Sep 24, 2020·International Journal of Molecular Sciences·Sergey BrezginVladimir Chulanov
Apr 17, 2019·Wiley Interdisciplinary Reviews. RNA·Samantha L Schwartz, Graeme L Conn
Feb 11, 2020·Frontiers in Cell and Developmental Biology·Mariska van Huizen, Marjolein Kikkert
May 9, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jung-Hyun LeeMichaela U Gack
Mar 1, 2016·Biophysics Reviews·Umeharu Ohto, Toshiyuki Shimizu
Jun 28, 2019·Current Protein & Peptide Science·Eskandar TaghizadehSeyed Mohammad Gheibi Hayat
May 15, 2020·Pathogens·Shasha LiHaixue Zheng
Sep 29, 2020·Frontiers in Pharmacology·Priya GattiMarc Germain
Feb 7, 2018·Frontiers in Immunology·Marjan GharagozlooDenis Gris
Dec 20, 2018·Frontiers in Immunology·Yu-Ting KaoChia-Yi Yu
Apr 23, 2020·Pathogens·Irene Lo CignoMarisa Gariglio
Mar 11, 2020·Frontiers in Immunology·Kyle SaylorChenming Zhang
Oct 6, 2020·Frontiers in Immunology·Tünde FeketeKitti Pázmándi
Nov 26, 2020·Scientific Reports·Norbert MoldovánZsolt Boldogkői
Jul 25, 2019·Fish & Shellfish Immunology·Sarah J PoynterStephanie J DeWitte-Orr
Jan 26, 2021·Frontiers in Cell and Developmental Biology·Yuan QiaoJingtao Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

CRISPR Ribonucleases Deactivation

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Simon B RasmussenSøren R Paludan
International Reviews of Immunology
Himanshu KumarShizuo Akira
European Journal of Cell Biology
Hendrik Poeck, Jürgen Ruland
© 2021 Meta ULC. All rights reserved