Intracellular development of Trypanosoma cruzi in the presence of metals

Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology
Laís Pessanha de Carvalho, Edésio José Tenório de Melo

Abstract

Trypanosoma cruzi is transmitted to vertebrate hosts during the feeding of blood-sucking insects. After the invasion of host cells, the parasite resides within the parasitophorous vacuole until to escape to host cytoplasm and to proliferate, establishing an infection. Studies demonstrated that some intracellular parasites have to acquire all essential nutrients as well as transition metals from the host cell to be pathogenic, to maintain the homeostasis and to replicate. The present study investigated the progressive steps of the intracellular parasite development and establishment of infection in the presence of ZnCl2, CdCl2 and HgCl2. LLC-MK2 cells were infected with trypomastigotes during 6-84 h to investigate the steps of intracellular parasite development. After the host cells were infected during 12 h and treated with metals during 24 or 60 h or they were treated for 24 h and cultured for 72 h more to observe the reversibility. The results showed that the non-synchronous invasion of trypomastigotes resulted in an increasing number of intracellular parasites in intermediary forms (until 24 h post-infection), the appearance (from 36 h) and proliferation (84 h) of the amastigotes. The 24 h-treatments were not enough to impai...Continue Reading

References

Mar 15, 1989·Molecular and Biochemical Parasitology·N W Andrews, M B Whitlow
Mar 1, 1994·The Journal of Experimental Medicine·I TardieuxN W Andrews
Jul 1, 1996·The Journal of Cell Biology·A RodríguezN W Andrews
May 4, 2001·International Journal for Parasitology·K M Tyler, D M Engman
Jun 23, 2001·Molecular and Biochemical Parasitology·M R Ariyanayagam, A H Fairlamb
Jul 24, 2003·Journal of Cell Science·Aaron M WoolseyBarbara A Burleigh
Apr 22, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Juan Diego MayaAntonio Morello
May 6, 2006·Biochimica Et Biophysica Acta·David J Eide
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Aug 25, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Alessia FormigariAlessandro Santon
Nov 7, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C S CarvalhoA J S Góes
Jun 5, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Jean-Marc Moulis
Sep 3, 2010·International Journal of Cell Biology·Wanderley de SouzaEmile Santos Barrias
Mar 19, 2011·Toxicology·Klaudia Jomova, Marian Valko
Feb 18, 2012·Metallomics : Integrated Biometal Science·Ebany J Martinez-FinleyMichael Aschner
Jun 12, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Darliane A MartinsLetícia R Teixeira
Jan 22, 2013·Cell Host & Microbe·Kacey L CaradonnaBarbara A Burleigh
May 15, 2013·Nature Reviews. Microbiology·Joseph A LemireRaymond J Turner
Aug 5, 2015·Journal of Immunology Research·Ana Flávia NardyAlexandre Morrot
Oct 31, 2017·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Laís Pessanha de Carvalho, Edésio José Tenório de Melo

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Citations

Aug 30, 2019·The Journal of Microbiology·Laís Pessanha de Carvalho, Edésio José Tenório de Melo

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