PMID: 6990413Mar 1, 1980Paper

Intracellular distribution of nerve growth factor in rat pheochromocytoma PC12 cells: evidence for a perinuclear and intranuclear location

Proceedings of the National Academy of Sciences of the United States of America
P C MarchisioP Calissano

Abstract

The distribution of nerve growth factor (NGF) in rat pheochromocytoma cells (clone PC12) has been studied with two different techniques: immunofluorescence and autoradiography. It was found that NGF is progressively internalized in the cytoplasmic compartment and eventually accumulates in the form of discrete dots around the nucleus. A fraction of the internalized NGF appears within the nucleoplasm, often contiguous with the nucleolus. It is suggested that cytoplasmic and perinuclear NGF may be be in contact with a pool of tubulin or actin-like proteins in their soluble or organized form and play a key role in the process of arrest of division and neurite growth.

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Citations

Feb 1, 1981·Journal of Neurocytology·P C MarchisioP Calissano
Jan 1, 1988·Molecular Neurobiology·A LeviP Calissano
Jun 10, 2006·Cellular and Molecular Neurobiology·Patrícia Aline Boer, José Antonio Rocha Gontijo
Jan 13, 1994·Biochemical Pharmacology·G Morel
Jun 7, 2000·Neuropathology and Applied Neurobiology·J Woulfe, D Munoz
Jul 9, 1981·The New England Journal of Medicine·A C King, P Cuatrecasas
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E HazumP M Conn
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S NasiP Calissano
Jan 1, 1988·The Journal of Cell Biology·L W Jiang, M Schindler
Mar 1, 1986·The Journal of Experimental Medicine·M FujiiY Hinuma
Jan 1, 1990·Annals of the New York Academy of Sciences·C L WeillD H Russell
Jan 30, 2002·The American Journal of the Medical Sciences·Richard N Re
Dec 15, 1981·Biochemical and Biophysical Research Communications·J N LaverriereA Tixier-Vidal
Feb 1, 1989·Archives of Biochemistry and Biophysics·E M Rakowicz-SzulczynskaH Koprowski
May 1, 1981·Journal of Neurochemistry·F Michetti, R Donato
Feb 1, 1986·Journal of Neurochemistry·M B RosenbergX O Breakefield
Mar 1, 1983·Journal of Cellular Physiology·C E Chandler, H R Herschman
Oct 1, 1986·The British Journal of Surgery·A M Al-SumidaieS A Jenkins
Jan 1, 1990·Molecular Carcinogenesis·E M Rakowicz-SzulczynskaH Koprowski
Jan 1, 1991·Molecular Carcinogenesis·E M Rakowicz-SzulczynskaH Koprowski
Jan 1, 1987·Journal of Neuroscience Research·R W Stach, J R Perez-Polo
Nov 18, 2000·Journal of Neuropathology and Experimental Neurology·J D LipaniD A Lee
Jul 6, 2000·Journal of Neuroscience Research·R J ThompsonS C Barnett

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