PMID: 8989823Jan 1, 1996Paper

Intracellular factor XIII: cellular distribution of factor XIII subunit a in humans

Seminars in Thrombosis and Hemostasis
R Adány

Abstract

In addition to the plasma where factor XIII subunit A is present as part of the heterodimers of the tetrameric fibrin-stabilizing factor, homodimers of factor XIII A can also be detected in cellular localization in different human tissues. Experimental findings verified that these cells belong to the megakaryocyte/ platelet and the monocyte/macrophage cell lines. Additionally, factor XIII A is present in hepatocytes localized mainly around central veins in the liver and occasionally expressed in certain malignantly transformed cells. It is reasonable to suppose that factor XIII A acts not only as a member of the clotting cascade, but also as a cellular enzyme that can catalyze molecular interactions intracellularly (during the assembly/reassembly of the cytoskeleton) or extracellularly (in the connective tissue matrix around the cells containing it).

Citations

Feb 15, 2001·Pathology Oncology Research : POR·M F LoretoL Ginaldi
Mar 20, 2012·Thrombosis Research·Zsuzsa BagolyLászló Muszbek
Nov 19, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·D TöröcsikR Adány
Jan 23, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M V NurminskayaT F Linsenmayer
Nov 30, 2018·Journal of Thrombosis and Haemostasis : JTH·J L Mitchell, N J Mutch
Jul 12, 2011·Physiological Reviews·László MuszbekÉva Katona
Apr 11, 2014·BioMed Research International·Kayena D ZaqueoRodrigo G Stábeli
Jan 30, 2004·American Journal of Reproductive Immunology : AJRI·Kristijan CupurdijaPeter Sedlmayr

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