PMID: 7540275Mar 16, 1995Paper

Intracellular injection of inositol 1,4,5-trisphosphate increases a conductance in membranes of turtle vomeronasal receptor neurons in the slice preparation

Neuroscience Letters
M TaniguchiK Kurihara

Abstract

Inositol 1,4,5-trisphosphate (IP3) was injected into turtle vomeronasal receptor neurons in the slice preparation under a whole-cell patch clamp, and the evoked current was measured. Application of 0.1 mM IP3 evoked a prolonged, inward current (52 of 98 neurons) with an average peak amplitude of 89.9 +/- 10.9 pA. The reversal potential of the response induced by IP3 was estimated to be -32.3 +/- 1.5 mV (6 neurons). Bathing the neurons in 10 microM ruthenium red solution greatly reduced the IP3 evoked inward current to 18.0 +/- 4.6 pA (5 neurons). This is the first study to demonstrate that the membranes of the turtle vomeronasal neurons carry IP3-activated conductance.

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Citations

Mar 10, 2001·The Journal of Comparative Neurology·F A MurphyD A Fadool
Sep 3, 2003·Progress in Neurobiology·Mimi Halpern, Alino Martínez-Marcos
Aug 1, 1996·Current Opinion in Neurobiology·E R Liman
Mar 11, 2000·The European Journal of Neuroscience·M KashiwayanagiA Matsuda
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·A BerghardE R Liman
Jun 24, 2005·Journal of Neurophysiology·Antonieta LabraDebra A Fadool
Mar 6, 2007·Biochemical and Biophysical Research Communications·Takeshi ShiraiwaManabu Murakami
Jun 8, 1999·The Journal of Physiology·K InamuraK Kurihara
Mar 29, 2002·Journal of Neurobiology·Masayuki Koganezawa, Ichiro Shimada
Apr 30, 1998·Physiological Reviews·D Schild, D Restrepo
May 1, 1997·Journal of Neurophysiology·R L MossM Novotny
Mar 6, 2002·Journal of Neurophysiology·Angel R CinelliMimi Halpern
Jan 28, 2003·The Journal of Experimental Biology·Kennedy S WekesaAudrey Napier
Jun 25, 1999·Biochemical and Biophysical Research Communications·K Tsujikawa, M Kashiwayanagi
Aug 1, 1996·Chemistry & Biology·D R Kelly

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